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Strategies to improve feed efficiency in shrimp farming

Submitted by aledford on Mon, 11/30/2020 - 14:08

Shrimp farming has increased significantly over the last decade and is one of the largest-growing sectors of the aquaculture industry. Shrimp farming is a never-ending learning path, and the biggest daily challenge is mitigating disease risks while maintaining efficiency. With the increased frequency and combinations of diseases, effective management of all aspects of the farm including feed management in shrimp farming is key to producing shrimp efficiently. In light of the current market situation, COVID-19 has brought a huge amount of uncertainty to aquaculture production. Along with these uncertainties come new challenges — but also new opportunities, and this moment has the potential to change the way we farm. However, change should only occur in controlled conditions and in a sustainable manner to ensure the highest levels of productivity.

Strategies to improve efficiency

There are several concerns at the top of producers’ minds when making any changes in the production system, including disease risks, production costs, water quality and the potential impact these can have on profitability. In many markets, shrimp consumption and processing have decreased due to trading restrictions and reduced demand from eateries. Some producers are moving toward reducing their stock density and are adopting new techniques to reduce production costs. This trend has led our shrimp customers to implement different types of strategies to improve their margins:

1. Feed costs are the highest operational cost in producing fish and shrimp.

The quality of the feed will determine the overall benefit provided to the farm. However, a good-quality feed without solid feed and pond management practices and consistent and practical feeding regimes will have no impact on a farm’s profitability. Good-quality feed and feed ingredients with proven nutrition and researched feed formulation, combined with the correct feed management practices, will provide shrimp with a balanced nutrient profile, allowing them to thrive and grow and enabling shrimp farmers to see an increase in feed efficiency and a good economic return on their production.

2. Improving shrimp intestinal health:

Over the last decade, Alltech has been working with shrimp producing facilities to help increase their efficiency and profitability on-farm. By leveraging Alltech technologies, we can positively change the intestinal bacterial flora of the shrimp microbiome and strengthen the intestinal infrastructure to maximize the absorption capacity of nutrients.

To achieve improved intestinal health, it is necessary to use the natural synergy between prebiotics and probiotics to activate bacteria charities in a controlled environment and apply them to shrimp to maximize their benefits. This is known as a synbiotic system, and there is a growing interest in using synbiotic technology to achieve the desired outcome.

Could improving the shrimp pond environment make a difference?

Synbiotics is a practice that provides the synergetic benefits from a specific prebiotic colonized with beneficial bacteria through the fermentation process. The fermented products can be directly applied in ponds or administered in feed.

Advantages of using a synbiotic system:

  • Low-cost method
  • Aids in mitigating diseases challenges
  • Helps to improve overall survival rates of shrimp
  • Helps to improve shrimp growth

Alltech Aquate® Fertilizer has been specially formulated for the organic fertilization of aquaculture ponds. Tested in commercial environments, this product has proven to be a technology that can enhance, enrich and balance the entire cultivation system while promoting a good environment and improving productivity and product quality. In a study carried out on a Brazilian shrimp farm in the municipality of Tibau do Sul (RN), shrimp from two pools were compared: one with organic enrichment (rice bran fermented with Aquate Fertilizer and rations) and another with only rations (control). The positive results included a 30% increase in the weight of the shrimp in the nursery phase with Aquate Fertilizer, which resulted an increased growth rate and shrimp being harvested twenty days earlier than expected.

Similarly, in another study carried out on a Brazilian shrimp farm in the Arez City (RN), we compared organic fertilizations with rice bran fermented with and without Aquate Fertilizer. The group provided Aquate Fertilizer showed positive results, including weight gain and soil organic matter reduction.

Figure 1: Average weight variation in trials completed using Aquate Fertilizer in Arez City (RN).

Figure 2: Survival rate in trials completed using Aquate Fertilizer in Arez City (RN)

A balancing act

The skin, gut and gills are the main barriers of defense for fish and shrimp. To be able to function optimally, they need to be supported. It is key to strike a balance between the intestinal microflora, gut morphology, the immune system and nutrient uptake. This will help to influence the performance and welfare of fish and shrimp. There are many forms of Aquate® to suit individual markets with various needs. Supplementing Aquate® at optimal inclusion levels in the diet will result in healthier aquatic species, decreased feces production and less pollution.

Aquate, from Alltech, has been used in the aquaculture industry for more than a decade. This sustainable yeast-based feed supplement provides a balance of essential amino acids and microminerals to help promote gastrointestinal integrity and stability, enhance nutrient utilization and boost natural defense systems, leading to elevated performance and profitability on-farm.

Aquate technologies are species-specific, addressing issues related to:

  • Growth
  • Feed conversion ratio
  • Immune system
  • Fillet quality and composition

Aquate has been proven to improve biomass production, boosting feed efficiency and helping maintain a protective balance between the species, its nutrition and the environment in which it lives. 

Seafood provides our population with a large concentration of omega-3 fatty acids and can help to reduce cholesterol and inflammation in the body. Fish are an excellent source of high-quality protein and other micronutrients that our bodies require.  Shrimp, in particular, is one of the most nutrient-dense foods available for the human population — but the nutritional quality of both fish and shrimp depends largely on what the fish eats during its lifetime.

It is important during these challenging and uncertain times that we stand strong as an industry and continue producing responsibly farmed seafood that meets the nutritional needs of our population. This is now more important than ever as we all work together to contribute to sustaining the aquaculture industry for generations to come. If you would like to discuss which Aquate product will best suit your aquaculture production facility, please email aquasolutions@alltech.com.

 

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Shrimp, in particular, is one of the most nutrient-dense foods available for the human population — but the nutritional quality of both fish and shrimp depends largely on what the fish eats during its lifetime.

How to control ammonia levels in poultry houses

Submitted by aledford on Mon, 09/14/2020 - 19:20

One of the biggest complaints surrounding the poultry barn — apart from flies — is the smell of the manure. The ammonia concentration in poultry houses not only contributes to the smell but can be harmful for both the birds in the barn and the workers who frequent the barn. Understanding how ammonia gas is formed, the impact it can have on the bird and how to control ammonia levels can be helpful for proper poultry management.

How is ammonia gas formed?

Nitrogen is a component of poultry diets, via either protein or other sources. Some of this nitrogen can be used by the bird and is incorporated into tissues or eggs, but most of it is excreted in the urine or feces in the forms of uric acid (around 80%), ammonia (around 10%) and urea (around 5%). Once the uric acid and urea are excreted, they are converted into ammonia through microbial and enzymatic breakdown via the bacteria and enzymes found in manure. After this process, ammonia is readily released into the air as a gas that can be detected by both birds and farmworkers.

Factors that influence how ammonia is formed and released into the poultry house environment Factors that influence how manure bacteria and enzymes break down nitrogen to form ammonia
  • Litter type
  • Bird activity
  • Stocking density
  • Manure handling
  • Frequency of manure removal
  • Ventilation rate
  • Nitrogen content
  • Temperature
  • Moisture/humidity
  • pH

What impact can ammonia have on the bird?

The results of poultry research studying how ammonia levels can impact production are varied. Some groups suggest that 25 ppm should be the maximum, whereas other groups suggest that exposing birds to 20 ppm for long periods of time could lead to issues like a debilitated immune system and respiratory tract damage. Other research suggests that, when poultry can choose between environments featuring different levels of ammonia, they choose environments with ammonia levels under 11 ppm.

Ammonia is toxic to animals. High levels of ammonia may lead to observable changes, such as difficulty breathing, irritation of the trachea (the breathing tube), air sac inflammation, inflammation of the mucus membranes of the eye or a combination of these symptoms. Many other, less obvious changes can take place upon exposure to lower levels of ammonia. Studies have found that exposure to 20–25 ppm throughout production can result in increased susceptibility to secondary challenges (viral or bacterial), decreased feed efficiency and tissue damage. These changes have been noted in broilers exposed to ammonia levels between 20–30 ppm for 16–28 days. Studies of turkeys have found that, among birds dealing with an E. coli challenge, those that were exposed to ammonia levels between 10–40 ppm had more bacteria in their lungs than the birds that were not exposed to ammonia. In layers, it has been suggested that early exposure to ammonia could have a lasting effect and might impact how pullets perform later as laying hens. Additionally, chronic exposure to high ammonia concentrations may impair egg production for layers. 

At a microscopic level, researchers have found that exposure to ammonia can trigger changes within the animal. In poultry, high-level exposure to ammonia for 20 days decreased the intestinal surface area (possibly impacting nutrient absorption), decreased the bird’s resistance to oxidative stress, altered the intestinal tract’s ability to break down nutrients and impacted immune organs. Exposure to high concentrations of ammonia for even a short period of time may impact birds just as much as exposure to medium concentrations of ammonia for longer periods.

Harmful effects of ammonia concentrations in poultry and humans

5 ppm Lowest detectable level.
6 ppm Irritation of the eyes and the respiratory tract.
11 ppm Reduced animal performance.
25 ppm Maximum exposure level allowed for a period of one hour.
35 ppm Maximum exposure level allowed for 10 minutes.
40 ppm Headache, nausea and loss of appetite in humans.
50 ppm Severe reduction in performance and animal health; increased possibility of pneumonia
100 ppm Sneezing, salivation and irritation of mucus membranes in animals
300 ppm or more An immediate threat to human life and health.


How to reduce ammonia levels in poultry houses

There are several strategies for decreasing ammonia in the barn. These strategies can be used individually or in combination and can help encourage good barn air quality and better poultry performance potential. These strategies include ventilation and management of both the barn and the poultry litter/manure.

Ventilation acts as an in-barn air quality control, removing ammonia from the barn and bringing in clean air. This method does not, however, reduce or inhibit the formation of ammonia. Nevertheless, maintaining appropriate ventilation during all seasons will help reduce the gaseous ammonia levels in the barn and keep the litter dry.

Good barn management can help to diminish the formation of ammonia gas. Proper barn management includes ensuring that the litter or manure is not wet. Several ways to keep litter from getting wet are to fix leaky drinkers and sprinkler systems; choose the appropriate litter; maintain a suitable barn relative humidity for the age of the bird; reduce the potential for condensation; and properly heat and ventilate the barn.

Strategies for managing the litter and manure can be separated into two main management actions:

  • Managing the bird diet: The formation of ammonia in the manure and its subsequent release as a gas can be traced back to increased nitrogen levels in the manure. Fecal nitrogen levels can increase if the bird does not properly break down and absorb the protein in the feed. This can happen if the bird’s diet features too much complex protein, if the bird is sick or if its gastrointestinal tract is not functioning properly. These issues can be remedied or prevented by balancing the protein and/or amino acid levels in the diet and by maintaining the bird’s gastrointestinal health. 

Another method to help prevent ammonia emissions from nitrogen within the feces is to use components such as the extract of Yucca schigidera, which plays a role in binding ammonia. De-Odorase® is derived from Yucca schigidera and has been shown to reduce blood urea and blood ammonium ions, reduce excessive nitrogen breakdown in the ceca and bind ammonia so it stays in the manure instead of being released as gas. When it is used in the feed from the time the birds are placed to the time the birds leave the barn, it can control the release of ammonia into the air.

  • Managing the manure once it is in the barn: Acidifying agents can be used to lower the pH of the litter (below its usual 7.5–8.5), which will help slow down and decrease the activity of the microbes that break down the nutrients in the manure to release ammonia. Another strategy could be to use odor and moisture absorbents in the litter or manure. These absorbents, which are usually clay-based, act to either slow down the microbial activity or lower the moisture content of the litter. De-Odorase® can also be used as a spray over and on manure to help control ammonia that has been released and reduce its odor. There may also be microbial and urease enzyme inhibitors that can be used to prevent the action of the microbes and enzymes in the manure that help to release ammonia.

All these strategies, however, can be negatively affected by litter and manure accumulation, litter and manure moisture, bird type, barn temperature, disease challenges or a combination of these factors.   

Conclusion

Poultry farm ammonia emissions from manure and ammonia gas in the barn are complex topics in the poultry industry, but with a combination of good ventilation, good barn management and a strategy to reduce ammonia gas formation, this issue can be successfully overcome at any time of the year.

This blog is a summary of an article published in Canadian Poultry.

 

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There are several strategies for controlling ammonia in poultry. These strategies can be used individually or in combination and can help encourage good barn air quality and better potential poultry performance.

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How to increase hot carcass weight by 15 pounds

Submitted by aledford on Fri, 03/13/2020 - 08:39

Research shows that, in order to increase hot carcass weight in beef cattle, farmers need to work toward producing healthier animals by increasing feed efficiency.

Feedlot cattle use high-energy feed ingredients to reach their potential for meat production. With high production costs, animals must be as efficient as possible at utilizing the nutrients released from feeds in order to increase profitability at the feedlot. 

Cattle rely on the rumen to break down fiber; however, some undigested ingredients can bypass the rumen and cause:

  1. Hindgut fermentation
  2. Indigestion
  3. Less effective use of nutrients

Identify the problem

Scientists at the Alltech Center for Animal Nutrigenomics and Applied Animal Nutrition continuously analyze how specific food and diet formulations can change gene expression and alter performance. Research into the finishing stage has focused on aspects such as hot carcass weight and feed efficiency in beef cattle. Scientists have even discovered a way to predict responses to certain feed ingredients. Among the top 10 breakthroughs at the research center is a product whose name says it all: Amaize®.

Amaize, an extract of Aspergillus oryzae fermentation, contains alpha-amylase enzymes that modify starch digestion, maximizing feed efficiency and increasing production. Amaize fractions starch to change the volatile fatty acid profile in the rumen, which leads to physiological changes in the animal, breaking down feed ingredients to enhance cattle metabolism. Using traditional techniques, researchers were successful in demonstrating that adding Amaize to the diet resulted in carcass weight gain for beef cattle.

Conduct research in the lab

Examining rumen fermentation patterns and tissue samples using gene expression, however, showed that the mode of action for Amaize was much more complex than it originally appeared. The enzyme’s impact on the animal’s metabolic system showed that Amaize optimizes animal growth not by increasing digestion; rather, Amaize promotes specific rumen microbial populations that would typically be associated with fiber digestion. Modification in microbial populations resulted in changes in rumen fermentation patterns and end products, including increased butyrate concentrations and other metabolites.

The downstream effects of this shift include changes to the blood metabolites and genes related to energy utilization for growth. Gene expression evaluations have shown that genes related to the expression of insulin-like growth factor (IGF-1), insulin receptors and growth hormone receptors were affected positively in muscle tissue. Changes in gene expression suggest a correlation to improved energy balance, increased metabolic activity and, therefore, muscle growth.

Nutrigenomics has allowed scientists to more precisely understand the mechanism of action of Amaize, making it possible to issue specific recommendations to farmers regarding when and how to incorporate Amaize into their cattle’s diets, increasing growth efficiency in beef cattle.

Get out of the lab and into the field

While nutrigenomic studies have proven that an increase in hot carcass weight and dressing percentage were possible, field research confirmed the phenomenon of higher carcass weight in finished beef cattle, correlating to an increase in ROI. Since the discovery of the Amaize enzyme, numerous studies have been conducted in both university and commercial settings. These studies confirmed that the ideal dose rate for Amaize is 5 grams per head per day for feedlot cattle; there are no additional benefits associated with providing it at higher levels. 

While, individually, each of these studies showed the positive effects of feeding Amaize, it was when they were examined as a whole that the real value for the producer was uncovered. These studies included a variety of breeds, diets (including steam-flaked, rolled and high-moisture corn-based diets), locations and weather conditions — proving the consistency of Amaize in diverse conditions. The studies showed that, on average, the product has the ability to increase dressing percentage by 0.5% units and hot carcass weight by 15.5 pounds. In today’s cattle market, that extra 15.5 pounds of hot carcass weight means that Amaize achieved a 10:1 return on investment.

Encourages ruminal digestion Maximizes performance *Based on an average comparison of 14 trials

 

Using enzymes like Amaize to alter rumen fermentation and metabolism proves that it is a key component for optimizing finishing diets, driving carcass weight gain and maximizing return on investment. Find out how Amaize can help you increase your ROI.

 

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Amaize fractions starch to change the volatile fatty acid profile in the rumen, which leads to physiological changes in the animal, breaking down feed ingredients to enhance cattle metabolism, maximizing carcass gain and optimizing overall performance.

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Enzyme Management

Maximizing Feed Efficiency

One of the biggest challenges for the feed industry and animal nutrition as a whole is the rising cost of feed, which can account for up to 70% of total production expenses. Furthermore, around 25% of the available nutrients in feed ingredients cannot be fully utilized by the animal due to anti-nutritional factors.

Today, the greatest challenge for the feed industry — and especially for nutritionists — is to reduce this indigestible fraction and maximize feed efficiency based on nutritional and economic factors, which can often vary and may be unique to each production system.

Feed costs represent the biggest input for producers, often accounting for up to 70% OF TOTAL PRODUCTION COSTS.

 

Around 25% OF NUTRIENTS ARE LOST due to anti-nutritional factors in feed.


The Alltech Enzyme Management Allzyme Series


Join us in this Allzyme series to learn about the most efficient strategies for the inclusion of enzyme technologies and how you can protect your productivity and obtain long-term, sustainable results.

Watch Now!


How can we provide the growing world population with food while maximizing feed efficiency in a sustainable way?

Together, we can maximize feed efficiency. The Alltech® Enzyme Management program utilizes unique technologies backed by science that work in synergy with the animal’s digestive tract and target the complete diet to optimize the potential of the feed by reducing the anti-nutritional effects, improving nutrient release and feed digestibility. As a result, fewer nutrients are released into the environment, saving producers money while providing sustainable benefits for the animal and the planet.

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Our feed enzyme technologies have implications beyond cost savings. Our range of feed enzymes helps improve gut health, animal welfare and the environment, allowing you to potentially triple your bottom line.

Profit

Reduces feed costs
You can save up to $14* per ton of feed.
*Depending on the feed enzyme combination, the diet and the species.

Greater feedstuff utilization

Reduces variability

Performance

Optimizes feed digestibility

Promotes a healthy digestive system

Reduces gut viscosity, enabling animals to digest and absorb more nutrients

Planet

Reduces environmental impact

Less soybean meal, oil and phosphates needed

Lowers the manure output in terms of the excretion of nitrogen and phosphorus


 

Feed enzyme production: A unique solid state fermentation (SSF) process

Backed by science since 1980

Alltech has pioneered the production of enzymes. Our years of research and collaboration make it possible for us to provide producers with the most unique SSF enzyme technologies in the animal feed industry.

A unique solid state fermentation (SSF) process

How does it work?

1.
Strain selection

SSF is a naturally occurring process, breaking down substrate by the production and release of specific enzymes. In a production system, specific fungal strains are selected.

2.
Liquid Fermentation

These fungal strains are then grown in a liquid media.

3.
Substrate ready for fermentation

This substrate enters Alltech’s state-of-the-art tray fermentation chamber, where it incubates for up to five days.

4.
Solid state fermentation process

During this time, the fungus grows rapidly and secretes enzymes to break down the substrate (solid media) to release nutrients required for continued growth.

5.
Substrate drying process

The substrate is then dried and standardized for enzyme activities and passed through quality control.

The result is ALLZYME®
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Enzyme activity is not linear and does not fit well with a linear formulation program. Not all feed enzymes are created equal. So, understanding the undigestible dietary fractions present in feed ingredients and the complex interactions between enzymes, substrates and the gut can improve the digestibility of all nutrients.

<>Question
What factors should be taken into consideration when formulating feed with enzymes?
<>Answer

Phytase, carbohydrase and protease are some of the most common feed enzymes typically considered in the animal feed industry. Each of these three feed enzyme categories has a specific role and function in the animal that results in different benefits for producers. However, certain enzymes can only fit into certain substrates.

<>Question
What enzymes are used for animal feed?
<>Answer

Enzymes work on different types of raw materials, including high fiber, which contains anti-nutritional factors commonly found in typical corn, soy and wheat diets. 

<>Question
What types of raw materials perform better with feed enzymes?
<>Answer

The formulation of enzymes into the diet is based on the nutrient value “uplifts” and on maintaining equal or better performance at a lower diet cost. The matrix is calculated from the "uplift" in nutrient values determined by research and enzyme use rate.  

<>Question
How does formulating with enzymes work?
<>Answer

Adding enzymes to animal nutrition reduces the amount of soybean meal, oil and phosphates needed, enhances the use of alternative raw materials and helps increase the production yield for limited arable land. Enzymes also help lower the manure output in terms of the excretion of nitrogen and phosphorus while also helping producers save money by reducing the feed cost per ton.

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What role do enzymes play in sustainability?
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How can the Alltech Enzyme Management program benefit you?
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How to solve the greatest challenge in the feed industry

Submitted by lkeyser on Mon, 11/25/2019 - 13:50

Over the next few years, food production must almost double to meet the needs of the world population and the global demand for protein. This has put pressure on the livestock sector to maximize output while reducing the usage of resources, making animal feed the largest and most important component in the industry to provide healthy and sustainable animal protein.

One of the biggest challenges for the feed industry and animal nutrition is the rising cost of feed, which can account for up to 70% of total production expenses. Furthermore, around 25% of the available nutrients cannot be fully utilized by the animal due to anti-nutritional factors in the feed, which could be costly for the global livestock industry.

Today, the greatest challenge for the nutritionist in the feed industry is reducing this indigestible fraction and maximizing feed efficiency based on nutritional and economic factors, which often vary and may be unique to each production system.

Improving animal and feed performance with feed innovation

Scientific innovation is critical for the future of animal nutrition and protein production. Some key areas of focus for the global animal feed industry to improve animal and feed efficiency are:

  • Improving animal performance characteristics (e.g., feed-to-weight-gain ratios, smart feed for more nutritious animal products)
  • Minimizing costs (e.g., less expensive base ingredients, more efficient utilization of grain for feed)
  • Maximizing feed production efficiencies in a sustainable way (e.g., processes and practices)

While traditional feedstuffs continue to be used at high rates, new and novel feedstuffs are now routinely implemented in animal feed formulation. A range of innovative applications are being used to optimize and assess the continued development of efficient and sustainable advances. Advanced technologies, such as nutrigenomics, reveal the relationship between feed nutrients and gene expression. Nutrigenomics allows the industry to identify feeds that can help animals reach their genetic potential by directly impacting the genes responsible for growth rate, meat quality and disease prevention.

Another technology that will allow for the prompt characterization of the nutritional value of raw feed materials is in vitro digestion modeling. These models, which can be used for both poultry and swine, provide real-time decision-making options to maximize feed usage while also improving animal production.

A third area of feed innovation involves providing supplemental feed that contains exogenous enzymes, also known as feed enzymes, which aid digestion by promoting the release of nutrients that are typically unavailable to the animal, improving animal performance in a sustainable way.  

The role of enzymes in the feed industry

Enzymes, which are essential for life, serve a wide range of functions and are especially important to the feed industry, thanks to their ability to break down nutrients. Enzymes are naturally occurring catalysts that speed up the rate of most chemical reactions that take place within cells.

Enzymes play a key role in the animal’s digestive process. Although digestive enzymes are produced by the animal itself — or by naturally occurring microbial organisms in the animal’s digestive system — producers have also used exogenous feed enzymes for many years for nutrient utilization and improved performance in animal feed.

Using poultry nutrition as an example, feed substrates and enzymes can generally be thought of in three ways:

  1. Naturally produced endogenous poultry enzymes in the digestive tract of the bird for the liberation of nutrients from feed components, such as starches, proteins and lipids
  2. Exogenous enzymes not native to the animal’s digestive system that act on recalcitrant substrates, which are not easily digested but which could potentially be utilized as nutrients, such as the glucose in cellulose in poultry diets (e.g., use of cellulase enzyme in poultry nutrition)
  3. Exogenous enzymes not produced by the animal’s digestive system that could act on difficult-to-digest substrates, as well as any anti-nutritive effects, due to compounds such as β-glucans, xylans and phytate (e.g., phytase enzyme in poultry feed)

Performance and profitability are often the primary reasons for utilizing feed enzymes, as they are the direct result of the improved digestibility and the increased availability of nutrients like phosphorous, carbohydrates and amino acids and, in turn, an increase in available energy as well. However, feed enzymes also allow for the use of a broader range of feedstuffs, which can allow for flexibility in the formulation of the diet by using non-conventional sources or alternative raw materials. These alternative sources are a direct result of the growing demand for corn, wheat and soybean meal. The increased demand for grains has also increased their value, leading feed producers and nutritionists to look for alternative feedstuffs to reduce costs. Non-conventional dietary sources, however, might not be as readily digestible, as the animal may lack the necessary endogenous digestive enzymes and, as such, will glean less nutrition from the feed. The utilization of exogenous enzymes to make the feed more digestible increases the nutritional value of these non-conventional feed sources for the animal.

Over the past 20 years, enzyme supplementation in the animal feed sector has grown and developed dramatically. The global feed enzyme market is currently estimated to be more than US$1 billion and is expected to grow by another 8% over the next five years. Right now, phytase holds the largest market share; however, the use of proteases and NSP enzymes, such as xylanase, has accelerated to such an extent that they are being included in over 57% of monogastric diets. Enzymes in poultry feed has been the largest segment, followed by the swine and aquaculture industries.

Feed enzymes over the years

Early research studying the role of enzymes in poultry nutrition was already taking place in the 1920s. The R&D evolution continued through the 50s and 60s, when barley diets were commonly fed, and research showed that enzymes improved poultry performance. During the 80s and 90s, a better understanding of NSPs in fiber and their impact on animal performance became a focus of the research, and the use of xylanase also became prevalent. During the late 90s, the use of phytase became standard practice. Currently, in terms of the feed penetration of phytase and carbohydrase enzymes such as xylanase, the feed enzyme sector is a mature market. The benefits of providing exogenous enzymes in the feed include the reduction of anti-nutritional factors in the animal feed, the use of lower-cost feed ingredients and an improvement in feed conversion and animal performance — but in order to get the most out of your animal nutrition, it is important that you choose the right feed enzyme to meet your needs.

A unique process development

The majority of feed enzyme production originates by using both bacterial and fungal microorganisms produced either from the submerged fermentation (SmF) or solid-state fermentation (SSF) processes. 

Naturally occurring microbial strains for the production of enzymes are of great value and continue to be utilized, but the use of recombinant versions accounts for the majority of industrial enzyme production today. 

Solid-state fermentation systems can be tailored to address specific needs based on the substrate and microbial selection. For example, Aspergillus niger produces a cocktail of enzymes that contain multi-enzymes such as phytase, xylanase, cellulase, protease and β-glucanase. These enzymes, both as individual applications or as a concoction of enzymes, have a broad spectrum of industrial applications.

Early assessments characterized SSF as being a simplistic process, less technologically advanced than the SmF process, but that assessment was later shown to be erroneous and based on a poor understanding of SSF process requirements. Recent rigorous studies have shown that, with the proper design, the technical and economic advantages of SSF far outweigh those of SmF. The many economic advantages of SSF over SmF include a lower capital investment, lower energy requirements, a lower environmental impact based on water consumption and waste generation, and lower costs for downstream processing. Additional studies are needed to continue identifying opportunities for agro-industrial residues as substrates and to match the appropriate microbes to cultivation conditions. Tray fermentation has become the proven leader in large-scale SSF applications, and much work has been completed on the control of key parameters to optimize growth at a commercial scale. Innovations in engineering to allow for large-scale SSF processes offer a major opportunity for growth in the commercial enzyme industry.

Maximizing feed efficiency with enzyme technologies

Enzymes are well-known to be an effective solution for optimizing feed efficiency. Enzyme supplementation in animal diets increases nutrient digestion by breaking down anti-nutritive components, such as phytate and NSPs, into forms that are more readily absorbed by the animal, reducing the environmental impact as well, while saving on costs for producers. 

Feed efficiency starts with an accurate knowledge of raw materials and their quality, allowing for the precise adjustment of the feed formulation. How well an enzyme performs, in many cases, is determined before it even reaches the animal. Feed processing methods — whether milling, grinding or, particularly, pelleting — can have a major impact on enzyme stability. Furthermore, digestive tract conditions, particularly pH changes and substrate availability, can also influence enzyme efficiency.

Enzyme characteristics can vary widely depending on the source. Solid-state fermentation has the potential to offer competitive advantages based on cost and efficacy.

Click here for more information about the Alltech Enzyme Management Program.

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Food production is required to almost double to meet the needs of the world population and the global demand for protein, putting pressure on the livestock sector to maximize output while reducing the usage of resources. This will make animal feed the largest and most important component in the industry to provide healthy and sustainable animal protein.

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Dr. Kyle McKinney: The enzyme opportunity

Submitted by ldozier on Mon, 06/17/2019 - 21:51

The following is an edited transcript of Tom Martin's interview with Dr. Kyle McKinney. Click below to hear the full interview. 

Tom:              The food industry has a four-quadrillion-dollar problem. You heard that right. This number represents the losses due to unused or misused nutrients in animals. With hundreds of thousands of acres being dedicated to farmland each year, agriculture is an important force that is continually shaping our world. But could a new enzyme begin to unlock this four-quadrillion-dollar opportunity? Is this the real key to creating a Planet of Plenty™?

 

                       As the global director of Alltech's Alternative Raw Materials and Feed Efficiency platform, Dr. Kyle McKinney is focused on feed efficiency. He earned a Ph.D. in agricultural biotechnology, focusing on the development of microbial fermentation systems to produce complex enzymes that improve feed and nutrition. Dr. McKinney joins us to talk about new opportunities for food and our future. Thanks for joining us, Kyle.

 

Kyle:              Thank you very much.

 

Tom:             Before we talk about the future, where are we today? Where is the state-of-the-art in feed efficiency right now?

 

Kyle:              When we talk about this opportunity, we consider the future of food and feeding the population. This whole concept and idea comes from the fact that, over the next 20 to 30 years, we're going to add two to three billion more people to the population. People say, during that timeframe over the next 30 years, we will have to produce more food in 30 years than we produced in the history of mankind.

 

                       When we read about the future of food, we see the positives and we see the challenges, the opportunities and some downright scary aspects, such as not having enough calories — not having enough food. So, we look at this as an opportunity — an opportunity to utilize technology, specifically an enzyme, to help the animal digest more available nutrients from our fields. I don't look at the doom and gloom. I believe that we will have plenty of food, and I believe that, when we look at our feedstuffs and you look at how much we lose in terms of nutrients and calories now when we're feeding our animals, it's an enormous opportunity — a four-quadrillion-dollar opportunity.

 

Tom:             We're tossing around some enormous numbers here. I mentioned that number: quadrillion. For perspective's sake, that's 1,000-trillion dollars. If you place one quadrillion British pound coins on top of each other, they reach beyond our solar system. That's how much we're talking about. We're talking about four quadrillion dollars in losses due to unused or misused feed in animals. So, the scope and the proportion of this is beyond imagination. When we hear about unused or misused feed, what does that mean, and how does this happen?

 

Kyle:               If you put some context behind that number, we produce about 3 billion tons of grains per year. Much of that goes into feedstuffs to feed our animals. The problem is that we lose about 25 percent, on average, of the available nutrients because of fibrous components in the feeds. I use the terminology of a bird nest that traps nutrients and the animal can't digest.

 

                        So, when we look at and consider 3 billion tons of feed, of grain, and we consider the 25-percent losses, and you look at the calorie levels of all those grains, that's really where we get to in terms of this four quadrillion, which is an enormous number to even consider.

 

Tom:              It is, it is. We hear that there's a new enzyme that could transform this problem into something of an opportunity. What is the new enzyme and how was it identified?

 

Kyle:               Our focus has always been on getting the most out of our diets. To do that, you have to consider that there are lots of components in a diet that trap nutrients — lots of variations of fiber, if we want to go that simple. To break all those fibrous components down, we believe it takes many enzymes.

 

                        We focused on a technology called solid state fermentation. Solid state fermentation is an ancient technology. What we are able to do is utilize a non-GMO organism, a fungus. We grow that fungus on a high-fiber feedstuff, and it produces a whole host of natural enzymes that are designed to break down grains and feedstuffs because we start with that.

 

                        So, our approach is utilizing solid state fermentation to produce an enzyme complex, many enzymes, to work on the many fiber substrates that we have in a diet. We don't focus on just one or two. We're focusing on a dozen or more of these substrates that are trapping nutrients. We can break those down. We see the most benefit in terms of nutrient availability for the animal.

 

Tom:              And is this technology being applied?

 

Kyle:               This technology is being applied. We've been pioneers in this solid state fermentation system. We have a facility in Serdan, Mexico, that produces for Alltech globally. We do research in terms of looking at how we can improve that system. We do research looking at new microorganisms that may give us even better enzyme complexes to focus on and get more and more out of the diet. That's the challenge the industry has, and that's the challenge we pose for ourselves: how do we continue improving the efficiency of those diets? Which means, as we feed more animals to feed the growing public, we've got more grain sources, because we're getting more efficient. That's one way we're approaching this Planet of PlentyTM concept, using this solid state fermentation enzyme technology.

 

Tom:              And in this application, you're actually seeing those results.

 

Kyle:               Absolutely. We see it with our enzyme system. For example, we can improve the digestibility of this grain feedstuff 7 to 8 percent. So, if you take 7 to 8 percent of the amount of calories that we're losing in all of our grains in feedstuff, it's an enormous number. It's going to allow us to feed more animals in the future.

 

Tom:              I know that you spent some time working for Alltech in Costa Rica on a project focused on using the Alltech Crop Science portfolio to control disease and reduce chemical applications. It also allows your team to set up a fermentation lab to evaluate more sustainable microbial solutions for disease control. How has the knowledge gained from that work informed what you're doing now?

 

Kyle:               The tie between those two projects is simply our expertise in fermentation, in microbial fermentation. We learned a lot about producing microorganisms in our systems in Costa Rica that we were able to take to our facilities in Kentucky and our facilities in Mexico and others and be more efficient in how we produce our products. So, the tie there was simply the fact that we went to Costa Rica, we set up a fermentation system, we're very successful in utilizing this type of technology to reduce chemical input. What we gained is knowledge of how to become more efficient in our production models that allowed us to move to different locations that we have production locations in globally.

 

Tom:              Earlier, you referenced population growth in the world. I'm wondering how this new enzyme will factor in supporting a Planet of Plenty.

 

Kyle:               If you look at the numbers, in 2050, there's an expectation that we will require 70 percent more meat, more food — and that's something around 500 million tons more meat in 2050 than we're producing today. That's something around 1 billion more tons of milk than we're producing today.

 

                        In the last 60 years, we haven't had additional acres of land growing grains, so we've accomplished amazing feats in agriculture; with less land, we produced more meat. Moving into the next 30 years, who knows how much more additional land we'll free up for grain production to produce more protein? This SSF enzyme technology and enzyme complex is going to be critical for the simple fact that we don't know that we'll have more acres of land. We probably will find it somewhere. But we've got to get more efficient because we do know one thing: we're going to have to produce more meat and protein to feed the population.

 

Tom:              Kyle, what else are you keeping an eye on in terms of alternative raw materials? In a traditional industry like farming, why is it important to look for new ways of doing things?

 

Kyle:               The hot topics in alternative materials right now are insect proteins. In Kentucky, it's hemp. [Kentucky is] the number one hemp-producing state in the United States. How is that going to play into how we're feeding animals in the future is a key question, and it's our duty to keep an eye on and understand how some of these alternative materials will play a role as we feed animals. At the moment, we're still very traditional corn and soy. But the new technologies, specifically in terms of insect protein and insect meals, are going to be probably the fastest-growing segment in the next five to ten years.

 

 

Tom:              That's fascinating. I've been wondering if Alltech had an interest in hemp because it's so popular in Kentucky (where Alltech is headquartered) and it grows all over the state. Is there actual activity in this area?

 

Kyle:               Our activity began with Alltech Crop Science looking at some of our technologies for improving efficiency. That is a project that's ongoing. But in terms of animal feed and animal nutrition, our researchers are digging into how hemp will play a role. Right now, it's not going into diets, but we have to keep an eye on this and see how that changes and see how it fits into feeding strategies.

 

Tom:              Getting back to insects — also fascinating, and there certainly are plenty of them. But are there particular species that are of interest?

 

Kyle:               The number-one insect used right now is called the black soldier fly. Picking the right insect is all in determining the growth rate of the insect — how much protein is in that fly meal. So, black soldier fly is the number-one insect producer at the moment.

 

Tom:              What would you say are the trends that you're keeping your eye on right now?

 

Kyle:               I think the trends that we're looking at in Alltech really revolve around technology and agriculture. How are we getting more efficient in monitoring animals, feeding animals, observing the nutritional needs of the animals, and what new technologies are going to allow us to do that? So, I think we, internally, have some programs where we're looking at innovation for sensors, for example. But it all gets back to us focusing on how we are improving the nutritional component of that animal and improving profits for our farmers and our growers.

 

Tom:              Dr. Kyle McKinney, Alltech's Alternative Raw Materials and Feed Efficiency platform global director. Thank you so much for joining us.

 

Kyle:               Thank you.

 

 

Dr. Kyle McKinney spoke at ONE: The Alltech Ideas Conference (ONE). Click here to learn about ONE and how you can access innovation on demand. 

 

Click here for more information about the Alltech Enzyme Management Program.

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The enzyme evolution in animal feed

Submitted by eivantsova on Wed, 06/22/2016 - 09:29

Even though the first exogenous enzyme was synthesized in 1969, enzymes in animal nutrition have been used in animal nutrition for less than 30 years. Their original purpose was to degrade so-called anti-nutritional molecules from grains used in feedstuffs, such as wheat, barley and wheatgrass. These grains, when used as a primary source of carbohydrates in an animal diet, presented less digestibility and nutritional content when compared with other grains such as corn and sorghum. As a result, they often led to decreases in animal performance.

A brief history of enzyme use in animal feed

The first enzymes developed by the biotech industry were the arabinoxylans and beta glucanases. Their function was to degrade non-starch polysaccharides, which are the fibrous portions of the grain. These enzymes reduced the viscosity of the non-digested grain in the intestine. The first trials proved that adding exogenous enzymes to wheat-based diets improved digestibility in monogastric animals. These early studies also helped scientists understand the mode of action of these enzymes and enabled them to develop new enzymes capable of working on a wider variety of substrates.

At the beginning of the 1990s, the main topic of conversation among nutritionists and researchers was what they considered to be the inevitable decline of sources of phosphorus in animal feed. The additives and supplements industry responded quickly to this challenge by focusing on enzymes capable of releasing more phosphorous through a molecule usually not present in livestock animals: phytate. Fungal phytase were able to chemically breakdown the phytate, releasing additional phosphorus in feed for pigs and poultry. While the nutritional matrixes of phytase would not be consolidated until 2000, they showed promising initial values of 0.05 phosphorus and a maximum of 0.10 percent available phosphorus.

The benefits of enzymes

Even though there are still some segments of the pig and poultry industries that do not use exogenous enzymes, the growth of the enzyme market has been substantial. Since enzymes improve the digestibility of plant-based feed ingredients, they offer immediate economic benefits to animal production. Enzymes have allowed producers to further improve their feed conversion rates, the uniformity of their flocks and herds, and the efficiency of their feed mills since fewer grains are needed to be purchased and processed.  

With all these benefits available to producers, the animal nutrition industry is becoming more eager to study enzyme technology in greater depth with the aim of further optimizing animal production. Research is ongoing on the effects of degradation of different substrates, different methods of producing enzymes, epigenetic effects of enzymes in the formation and development of the intestine, and interaction with the microbiota and intestinal health, as well as their direct or indirect action on the immune system. As our understanding of enzymes evolves, we should expect a revolution in how we feed our animals.

Click here for more information about the Alltech Enzyme Management Program.

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