While prebiotics and probiotics have been key additives in the pet food industry for several years now, the innovation of postbiotics seems to be a gut health game changer.

And while it may seem confusing to add a third gut health moderator to the mix, pet owners are more concerned with boosting their animals’ immune systems than ever before, warranting new technologies to improve pet gastrointestinal (GI) health.

As research grows in the field of postbiotics, it is safe to say that the newest member of the gut health family is here to stay, completing the holy trinity of the microbiome.

What are postbiotics?

Postbiotics are functional, metabolic by-products of gut fermentation. In other words, probiotics (i.e., the good bacteria in your gut) digest and utilize prebiotics (i.e., bacteria food), and the end result of that interaction is the release of postbiotics into the gut environment.

The name says it all: Postbiotics are “biotics” — a.k.a living organisms — that are produced “post,” or after, gut microbe interactions.

Postbiotics include compounds such as:

• Short-chain fatty acids
• Enzymes
• Vitamins
• Microbial cell fractions
• Organic acids

These compounds act in health-promoting ways, many of which have yet to be discovered.

In the pet digestive tract, the most notable postbiotics include acetate, propionate and butyrate. These three substances are classified as short-chain fatty acids, which are important sources of energy for the probiotic bacteria themselves, as well as for the epithelial cells that make up the gut lining.

Short-chain fatty acids are important because they work to optimize motility within the gastrointestinal tract and reduce inflammation, which is important for the prevention of any acute or chronic digestive condition. 

The pet gut microbiome

Research continues to find that the gut microbiome — in both humans and pets — is more complex than we originally thought.

Not only does the gastrointestinal tract play a role in virtually every function and system in the body, it also differs between individuals. The microbiome is dynamic and can change dramatically due to:

• Diet
• Stress level
• Age
• History of medication use

The gut microbiome is almost like an internal fingerprint, which means that digestive supplements will impact each animal in slightly varying ways.

That being said, research has found that the gut microbiomes of dogs and cats are very similar in composition and makeup — unless, of course, the animal is ill (Wernimont et al., 2020).

In dogs and cats with digestive disorders, such as chronic enteropathy and inflammatory bowel disease, the makeup of the gut microbiome has been shown to be significantly different in both its bacterial diversity and richness than the microbiomes of healthy pets (Minamoto et al., 2019; Garraway et al., 2018). 

For preventative reasons, probiotics are increasingly included in pet food ingredient lists and have been shown to assist in altering the populations of bacteria in the gut, shifting the GI tract from too many pathogenic bacteria to an abundance of good gut bacteria.

While probiotics are beneficial, their use can be controversial since probiotics are living organisms. This means that, from a technical standpoint, heat, food processing and storage limitations all pose significant challenges to the viability and stability of probiotics.

Prebiotics are selective ingredients that stimulate the growth of certain bacteria and, as a result, promote gut health. They are broad in scope, but the key here is that prebiotics are not alive, so they are less of a concern in terms of efficacy.

To put it more simply, pro- and prebiotics focus on altering the composition of the gut microbiome to prevent disease, while postbiotics are used for altering the function of the microbiome for overall good gut health.

Why use postbiotics in dog and cat food?

As research continues, what we know so far is that postbiotics positively affect signaling pathways within the GI tract. As metabolites, they interact with the bacteria in the gut, the gut itself and other body systems to trigger the immune system and promote whole body anti-inflammatory responses.

While the exact mechanisms through which postbiotics work have yet to be fully revealed, what is currently known about their wide range of immunomodulatory effects is good reason to include them in pet food (Wegh et al., 2019).

In summary

Postbiotics are heat-stable metabolites that deliver benefits straight to the GI tract.

All good things happen in threes! Protecting any dog’s or cat’s immune system and overall health is simple with the combination of research-backed probiotics, prebiotics and postbiotics.

I want to learn more about pet nutrition.

Newborn piglet care is a challenge on every farm. In the early stages of their lives, these young animals are more susceptible to health issues that would never affect older, more developed pigs. These challenges can come from all angles, as disease-causing organisms (such as bacteria, protozoa and viruses) are present in every part of the farm environment. From the sow to farm personnel, equipment, bedding and feed materials, there is no escape from these threats.

Even with the appropriate biosecurity measures in place, as piglets grow, they encounter other health-impacting sources. Changes in the diet, for example, can cause digestive disorders, manifested as diarrhea and failure to thrive and grow.

Due to the exposure to and consumption of external, potentially disease-bearing entities, such as water, feed and bedding, maintaining proper immunity is essential. Optimizing gut structures and microbial populations is vital for young animals, as it establishes the basis for their ongoing health and development. Piglets have very specific needs to establish good gut health and functions and to limit disease development. Providing the best gut health in young piglets can be achieved through various feeding interventions. Here are three crucial stages of developing good gut health in piglets to help put you on the right path.

1. Optimize colostrum from the sow

While in the womb, pigs benefit from the fully developed immune system of the sow. However, once born, piglets do not take any of these immunities along with them, essentially starting from scratch. To help encourage good gut health, the producer's task is to ensure that the newborn piglets have a good supply of immunoglobulins (Igs). These act as the first line of defense for young piglets, helping them to build their immune system to fight off the challenges they face in their environment. The best source of Igs is the colostrum supplied by the piglet’s mother, making it a crucial first step in optimizing gut health in piglets.

After the initial colostrum intake, piglet immunity status tends to diminish, making them more vulnerable to disease, which commonly manifests as:

• Diarrhea
• Dehydration
• Poor milk consumption

In addition, the switch from a milk-based diet to a grain-based diet at weaning means that their gut structures and microbial populations need to adapt quickly. This difficult period is referred to as the “weaning gap” in terms of health and immunity and occurs somewhere between 14–21 days of age.

To ensure that piglets continue to get the support they need and have a strong base to help them through the diet transition, the expression of Igs in the sow’s colostrum must be optimized. This can be achieved by including prebiotics and mannan-rich fractions (MRF) in sow gestation diets. Feeding trials (Spring et al., 2006) have shown that doing so increases the levels of all Igs in the colostrum and in the blood of the subsequent piglets that receive it.

2. Promote good gut health directly

As well as using them to optimize the mother’s colostrum, pre- and probiotics can be administered orally to piglets, promoting the development of the correct bacterial balances within the gut, establishing the best basis for future disease prevention, and maximizing health and growth.

Long-established research studying MRF has shown that it binds to the projections on the surface of disease-causing microbes, preventing them from attaching to the gut wall, which they need to do to reproduce, leading to harmless removal in feces. In addition, this binding activity interacts with the immune system in the gut, promoting faster responses to any disease threat. Multiple trials have shown that this activity of promoting better gut health increases feed intake, digestion and growth and improves feed conversion.

3. Use high-quality creep feeds

When piglets reach the age to begin weaning, creep feeding is introduced to prepare their digestive systems for the change in diet. This is another opportunity for the producer to bolster the young animal’s gut health by formulating creep feed with the best-quality raw materials, processed to maximize digestion and supplemented with proven feed ingredients. These can include:

• Nucleotides to facilitate gut tissue development
• Enzymes for maximum digestion
• Chelated minerals to ensure the best uptake and establish tissue mineral reserves during times of stress

These types of diets will ease the difficult period during weaning and will not compromise the gut environment, keeping disease at bay. Nucleotides are the building blocks of DNA and are essential for young animal development. They have been shown to significantly increase the growth of gut tissues and are important for repairing and preventing damage to the gut wall. A more robust gut structure is necessary to withstand the change from milk to grain-based feeds at weaning, when the erosion of essential structures (villi) for nutrient absorption can occur.

Seed, Feed, Weed

Over the last 40 years, Alltech has conducted extensive research studying gut health and has designed several gut health management programs that focus on supporting animal performance from birth by promoting favorable bacteria communities, building natural defenses and maximizing growth. The Seed, Feed, Weed (SFW) concept is one such program that is designed to modify the gut microbial population to establish favorable and more diverse microbial populations after birth. This program utilizes the advice above to help establish and maintain a beneficial and diverse gut microbiome in piglets. The SWF program supports gut health in piglets by:

• Seeding the gut with favorable organisms: It is vital to “seed” the intestine with the correct bacteria as soon as possible after birth. The first organisms to colonize the gut will determine the composition of the flora by creating the micro-environment necessary to establish a complex microbial community and optimal architectural development. With the right intestinal microflora now in place, piglets show improved early growth, feed conversion, uniformity and livability.  
• Feeding the favorable organisms: In addition to “seeding” the gut with the correct pioneer species, it is crucial to enhance the capacity of favorable organisms to colonize and rapidly dominate the microbial community in the small intestine. Once a beneficial microbial community and intestinal ecology is established, the villi will flourish. This step is critical for piglet health and feed efficiency because the healthier a piglet’s villi, the more efficiently nutrients will be absorbed.
• Weeding out the unfavorable microorganisms: The gut can also contain harmful pathogenic microbes (e.g., enterotoxigenic Escherichia coli), which can damage the intestinal villi. It is, therefore, important to “weed them out” before they can attach to the gut lining and replicate enough to cause disease. By blocking the attachment mechanisms of unfavorable organisms with a type-1 fimbria blocker, their capacity to compete with the favorable organisms (e.g., Bifidobacterium and Lactobacillus) in the gut is reduced. Minimizing the gut’s exposure to these harmful microbes will help to improve the animal’s natural defenses and shorten its recovery time from disease.

Figure 1. The Seed, Feed, Weed concept is designed to modify the microbial population in the gut to establish favorable and more diverse microbial communities after birth.

Providing solutions for each step of the Seed, Feed, Weed process, Alltech offers a range of products for both the sow and their young that help to optimize piglet nutrition and support gut health and development. These include:

• Actigen^®
• NuPro^®
• Allsyme SSF^®
• Bioplex^®
• Sel-Plex^®
• Viligen™

As they start life, baby pigs are extremely vulnerable. Any change in their environment potentially exposes them to a whole new group of pathogens, which can limit their performance. Furthermore, as they mature over the weaning period, they are typically moved into new environments and exposed to other equipment, animals and people. Ensuring that the best gut health is established as early as possible is key to limiting disease, increasing health and welfare and maximizing growth. This is essential for the young piglet and helps to ensure optimal lifetime performance and profitability for producers in a sustainable manner. The use of gut health management programs will also play a pivotal role in helping producers work toward antibiotic- and ZnO-free production.

I'd like to learn more about pig nutrition.

Have you ever felt like your barn smelled worse than it reasonably should? We are not talking about normal animal smells — I mean, who doesn’t love the smell of sawdust and fresh hay?

No, we are talking about the notorious stench of dirty stalls, specifically from excess horse urine and ammonia. In some cases, this strong odor can stick around even after you have thoroughly cleaned your horse’s stall. I think it is safe to say that every horse owner has experienced what I am referring to at some point in their life.

But did you know that ammonia is more than just an unpleasant smell? Exposure to ammonia, depending on the level of severity, can have serious health consequences for both you and your horse, making horse stall management a critical part of any overall barn management plan.

What is ammonia?

Protein is an essential component of any equine diet, but when protein is overfed, the horse’s body expels it through feces or urine in the form of urea. The natural bacteria in the environment feed on this urea, which results in the production of ammonia gas.

Although ammonia is not visible to the human eye, it can be readily detected by more than just the human nose. Ammonia is a noxious gas that can cause burning sensations in the eyes, lungs and throat. It has also been known to make people feel nauseous and dizzy and can induce vomiting and increase mucus production and fluid levels in the lungs.

Overall, ammonia is classified as a highly hazardous gas and is something that should be taken seriously for both human and equine health.

How does ammonia affect my horse? 

If your eyes start to water after spending just 10 minutes cleaning a horse stall, you can bet that the ammonia gas is also affecting the stall resident. Ammonia is a caustic gas and can cause damage by burning the eyes and respiratory tissues. It may also be a contributing factor to inflammatory airway disease and, eventually, chronic obstructive pulmonary disease (COPD).

Although the complete effects of ammonia are not yet known, it has even been linked to a negative effect on metabolic and reproductive hormones. 

Overall, high levels of ammonia negatively affect horses’ performance through its impact on the respiratory and immune systems.

What can I do to control ammonia levels? 

Luckily, you and your horse do not have to be victims to ammonia. The steps outlined below will help control odor in your barn and support better horse and human health:

1. Muck out horse stalls on a regular basis.

Remove any wet or soiled shavings, manure and urine piles at least once every day. If possible, muck stalls twice per day.

2. Ensure proper ventilation.

It is a good barn management practice to give each stall time to dry and “air out” without the horse present. Open any doors and windows, and do your best to enhance cross-ventilation with ceiling and aisle fans.

3. Design horse stalls for optimal drainage.

You may not have built your own barn, but even so, do your best to avoid letting urine pool or seep. Stall mats with gaps are perfect examples of places that urine — and, by default, ammonia — can hide. Invest in seamless stall mats and choose concrete floors, if possible, as wood and dirt stall floors are more likely to absorb urine. It is also wise to use more absorbent bedding to line the stall. Your bedding options will vary by region and location, but in general, straw is the least absorbent and should be avoided unless it is being used for a specific purpose, such as in a foaling stall. 

4. Dial-in nutrition.

As mentioned above, ammonia is a byproduct of protein. You want to feed your horse the correct amount of protein, but do not assume that more is better, as unused protein will result in increased ammonia production. An equine nutritionist or veterinarian will be able to help you determine your horse’s specific nutrient requirements.

5. Increase turnout time.

Horses need turnout for various reasons — and fresh air is a big one! Housing horses outside with adequate shelter permanently, or even for just part of the day, is a great management practice to increase overall health.

6. Look into unique solutions.

One of the most effective and cutting-edge solutions to your horse barn’s ammonia problems comes straight from the desert!

What does the desert have to do with my horse’s health?

De-Odorase^® is a completely sustainable product produced in Serdan, Mexico, from the native Yucca schidigera plant. This unique product contains compounds that have been proven to control odor from ammonia across several species.

De-Odorase^® can work on your farm in multiple ways:

1. When fed to the animal, it promotes protein digestion and metabolism, leading to less excreted urea in the waste.

2. When sprayed as a liquid in stalls before re-bedding, onto bedding already on stall floors or even into the air, De-Odorase^® binds ammonia, preventing noxious odors and related health problems.

You may not have guessed that the Mexican desert could play such a large role in your horse’s health, but De-Odorase^® — especially when combined with the management tips outlined above — can have a big impact.

Have a question or comment?

One of the primary goals of all livestock producers is to keep their herds healthy. Unfortunately, however, illness is often unavoidable — and some very easily transmitted but deadly ailments can be traced back to one source: Clostridium.

What is Clostridium, and how do you know when it is causing problems in your herd?

Clostridia are gram-positive, anaerobic, spore-forming bacteria that are often found in the soil and manure or in feedstuffs that have been contaminated.

“It’s around us all the time, everywhere,” said Dr. Luke Miller, a veterinary elite dairy advisor at Alltech. “Because it’s a spore former, soil contamination caused by clostridia can last through the winter. It can last in the desert, during heat stress, cold stress — all that stuff has very little effect on clostridia.”

Unlike many other disease-causing bacteria, clostridia are not contagious or passed from animal to animal.  

“There’s pretty much two ways you’re going to get a Clostridium infection,” said Luke. “You’re going to get it through either ingesting contaminated food or through a cut, an open wound or something like that. There’s always some insult that has to occur for a clostridial infection to flourish.”

It is possible for an animal to ingest clostridia and not be affected, as spores can lay dormant in the intestine. Clostridia become pathogenic when something about the animal’s diet, habitat or body changes — if the animal eats too much starch or carbohydrates, for example, or experiences a tissue injury, either internal (e.g., liver abscesses) or external (e.g., cuts or gashes). These issues — namely, a decrease in or lack of oxygen within the tissue — create favorable conditions for the proliferation of this bacteria.

Homing in on Clostridium perfringens

There are numerous types of clostridial bacteria, but cattle producers should be specifically concerned about Clostridium perfringens, which can have a major impact on an animal’s gut health — especially young animals, including calves that are less than 2 months old, because they have not yet developed a fully functioning rumen or a complete gut flora.

C. perfringens lives on starches and sugars, which explains why it proliferates when cattle start eating more carbohydrates. It can also spread when the animal experiences stress or is dealing with another condition that affects the gut, such as diarrhea. When elevated levels of the toxins released by C. perfringens enter the bloodstream — including alpha toxin, which is highly virulent — animals can experience inflammation, shock, cardiac arrest and even death.

What are the symptoms of clostridial disease in cattle?

Clostridium can lead to gut distress in cattle — especially when they are specifically dealing with C. perfringens, which can lead to symptoms and issues that include:

• Enterotoxemia (also known as purple gut; when toxins from bacteria that are usually found in the intestine enter the bloodstream)
• Severe diarrhea/stomach upset
• Abdominal pain
• Bloat
• Decreased appetite/intestinal movement
• Abomasum distention
• Leaky gut
• Bubbles in the manure
• Hemorrhagic bowel syndrome (HBS)
• Stalled calves
• ADR (“ain’t doin’ right”) — general malaise, etc.
• Blindness
• Sudden death

How can clostridial infections be prevented or defeated?

While it can be difficult to treat enteric diseases in cattle, including infections caused by C. perfringens, it is not impossible. Learn more about the various ways you can protect your animals against dangerous clostridia below.

1. Work with your vet to implement a vaccine protocol

Consult with your veterinarian about creating a proper vaccination program for your herd, as vaccines can help protect against some of the most common clostridial diseases in cattle, including enterotoxemia, blackleg, redwater and tetanus.

“There are many kinds and brands of vaccines for Clostridium,” said Miller. “Meet with your veterinarian to decide a proper vaccination protocol that addresses your operation’s needs and takes into account your regional pathogen load and issues.”

Miller also recommends being as proactive as possible about making sure your other cattle don’t contract clostridia once it has been identified in a member of the herd. After all, while clostridia can’t be transmitted from animal to animal, if the entire herd is eating the same contaminated feed or is walking on contaminated soil, more instances of infection are likely to crop up.  

2. Help the gut microbiome flourish by feeding probiotics

As defined by the National Institutes of Health (NIH), probiotics are live microorganisms that can provide health benefits by helping digest food, destroying disease-causing cells and producing vitamins. Some of the microorganisms contained in probiotics are similar to — or even the same as — microorganisms that live naturally in the bodies of humans and animals. As such, probiotics help “complement the gut biome,” in Miller’s words, making it more robust and bolstering its ability to fight off colonization by detrimental bacteria like C. perfringens.

“You can get colonization with good bacteria every day with probiotics, and they simply out-eat the competition for nutrients,” said Miller. “When they eat more starch, the Clostridium won’t be able to. They’re keeping the pH where they like it, not where the Clostridium likes it.”

3. Keep the gut healthy with products like Select BAC™

While the methods mentioned above can help protect against clostridial diseases in cattle, some intestinal issues caused by C. perfringens are not addressed by vaccines and/or probiotics. Select BAC™, a new product offering from Alltech, serves as a great nutritional solution for helping solve the problems created by Clostridium. This complete gut health pack includes both enzymes and probiotics, which play a pivotal role in maintaining the health of the gut.

“We’re throwing in the whole kitchen sink of what science thinks is good for the gut in Select BAC,” Miller said. “We’re helping you heal your herd’s gut.”

Clostridium is nearly impossible to avoid, and the effects it can have on cattle herds are difficult to grasp. Fortunately, a variety of Clostridium perfringens treatments and methods of prevention are available, including establishing a vaccination program and feeding probiotics and enzymes. Hopefully, by utilizing these techniques, producers can begin to feel more at ease about the health of their herds.

References

“Clostridial disease.” MSD Animal Health, http://www.msd-animal-health.ie/diseases/cattle/clostridial-disease/information.aspx.

“Clostridium perfringens infections in baby calves.” Drovers, 26 March 2013, www.drovers.com/article/clostridium-perfringens-infections-baby-calves.

Thomas, Heather Smith. “Calving Tips: How to Prevent Acute Gut Infection in Beef Calves.” Beef Magazine, 22 March 2013, www.beefmagazine.com/calving/calving-tips-how-prevent-acute-gut-infection-beef-calves.

Thomas, Heather Smith. “Clostridial Infections in Calves.” Angus Journal, 26 April 2017, www.angus.org/Media/News/FullArticle.aspx?asTitle=Clostridial-Infections-in-Calves&aiId=786.

I would like more information about Clostridium in cattle.

Getting the right start on-farm is key to optimal fish performance throughout their lifecycle. Each species of fish or shrimp requires a nutritionally balanced aquaculture feed that is tailored for each specific stage in their development. Providing nutritional solutions for the particular needs of larvae — their most critical life stage — benefits the fish during their entire lifecycle. An ideal start begins with optimal nutrition that supports the healthy development of all organs. Not meeting these nutritional requirements can potentially lead to deficiencies and deformities, such as poor growth and increased mortality, and, ultimately, result in decreased producer profitability.

Advantages of using a high-quality, nutritionally balanced aquafeed:

• Minimal nutritional deficiencies
• Optimal development and foundation for future growth
• High digestibility for optimal performance and water quality

Creating an optimal fish ecosystem

In fish farming environments, some variables can affect production, including temperature, oxygen, ammonia levels and water quality. Modern recirculating aquaculture systems (RAS) give greater control over these factors. The same can be said for aquafeed production; the quality of raw materials, nutritional formulations, transportation, performance, climate and feed mill operation can all impact the performance and productivity on-farm. Fish will perform best when an optimal environment is maintained; aquafeed and aquaculture supplements play a critical role in this.

Creating an optimal environment relies heavily on water quality. It is crucial for maximum growth, health and survival throughout the production cycle. Ingredient quality and nutrient availability aids digestion and nutrient absorption and utilization, resulting in healthier fish, but also lower feces production and less pollution in the systems and the environment. Getting the foundations right as early as possible helps fish reach their maximum potential.

Maintaining water quality

Maintaining water quality is largely connected with the quality of aquafeed. Any uneaten or undigested feed that is excreted into their environment is not only wasted but also causes unnecessary pollution and additional, unnecessary stress. For this reason, the feed must be highly palatable and suitable for the correct species and their developmental stage. Not meeting these needs from the start can have adverse effects on fish health.

Recent research completed at the Alltech Coppens Aqua Centre displayed the improvements in growth and performance when feeding two of Alltech Coppens’ starter feeds to rainbow trout (Oncorhynchus mykiss) during the hatchery phase. The results of this benchmark trial are shown in Figure 1.

Figure 1. Results of a starter feed benchmark trial performed in the Alltech Coppens Aqua Centre.

Supporting internal defense systems

A fish’s skin, gut and gills are the primary points of interaction with the external environmental factors that can impact on their health. Both internally and externally, these organs must be protected. Included in all Alltech Coppens feed is a premix known as Aquate®. Aquate has been specially formulated to meet the specific requirements of each aquatic species and life stage. It encourages healthier and more robust populations and boosts natural defense systems, aiding gut function. The best farm results are seen when feeds containing the Aquate package are fed throughout the entire life of the fish, as this feeding strategy creates continuity in the supply of their nutritional requirements.

Advantages of sustainable aquaculture

We live in a rapidly changing environment, with pressure on nature, wild fish stocks and food security. This should not be underestimated; we have an obligation to produce sustainable, well-balanced animal protein responsibly. This is a commitment that we take very seriously in Alltech.

A key element in producing sustainable fish and seafood is the reduction of fishmeal and fish oil in feed production. When reducing these key ingredients, close attention must be paid to the nutritional balance of the feed to ensure it meets the essential nutrient and energy requirements of farmed species. The cost of aquafeed in aquaculture is the single highest operational cost for a producer in the industry. Any small change can have a significant impact on profit yield. It is necessary to look at the nutritional profile and quality of raw materials to find a balanced feed for each farm.

Innovative research in the Alltech Coppens Aqua Centre has led to lowering our carbon footprint, lowering phosphorus and nitrogen emissions and a low inclusion of fishmeal and fish oil in feed formulations with no impact on the growth and performance on-farm.

I want to learn more about aquaculture nutrition.

Shrimp diseases are the shrimp farming industry’s biggest concern. In Asia, diseases cost the shrimp industry billions of dollars annually (Shinn, et al., 2018). There are numerous diseases that cause this economic loss. This article will provide guidance to help you prevent shrimp diseases by going back to basics with farm management practices, biosecurity and shrimp health management.

Common shrimp diseases in Asia

No single disease can be definitively named the most severe, as this depends on the area, the timing of the outbreak and the season. Some of the most common shrimp diseases found in Asia are acute hepatopancreatic necrosis disease (AHPND), which is caused by bacteria; white-spot syndrome virus (WSSV), which is caused by virus; and Enterocytozoon hepatopenaei (EHP), the fungal microsporidian. The table below summarizes the symptoms of and prevention methods for each of these diseases.

Disease can be brought on-farm by water quality, wildlife, equipment, people, stock and feces. They can manifest as external parasites, viral infections, bacterial infections or fungal infections. Therefore, the most practical way to prevent disease and/or reduce the losses they lead to is to implement proper farm management practices and enhance the immune system of the shrimp.

Farm management and biosecurity

The production cycle of shrimp farming consists of four components: broodstock, hatchery, nursery and grow-out. According to the Food and Agriculture Organization of the United Nations (FAO), each of these components would require clean water, clean rearing facilities, clean feed, hygienic protocols, and dry-out and break-cycle practice.

Shrimp disease treatment is not easy; often, it is more complex than disease prevention. There is not one single solution that fixes all problems, but there are preventive measures that keep pathogens from filtering through shrimp ponds and that keep shrimp healthy. FAO recommends the following best practices in shrimp culture:

• Choose the right shrimp genetics: i.e., specific pathogen-free (SPF) and high performers for high biosecurity systems. Better biosecurity in shrimp aquaculture begins with clean broodstock that supply eggs and nauplii for hatcheries. The broodstock, whether SPF or non-SPF, should be carefully sourced and certified. This is the first and most important step to take, as it could prevent the disease carriers from entering the culture system.
• Keep pathogens out: Dry out facilities regularly; disinfect fill and exchange water; control feed; and prevent air and droplet contamination.
• Biosecurity implementation: Limit the number of visitors (e.g., vehicles, humans, birds, other carriers) to a minimum.
• Hygiene: Install hand-wash stations, foot baths and wheel washes or tire baths; put up warning signs; disinfect footwear before entering the facilities; and wear boots.

Enhancing the immune system of shrimp

It is natural for pathogens and bacteria to be present in shrimp ponds. They might not even lead to any diseases for healthy shrimp with strong immune systems. Therefore, it is important to take good care of shrimp gut health and work to bolster their immune systems. This can be achieved by using the right feed additives.

One example is supplementation with zinc and selenium. Zinc plays a key role in modulating immune function, resulting in shrimp with increased immune capabilities. Zinc also helps maintain skin integrity and speeds up wound-healing. In addition to zinc, selenium supplementation has been proven to promote shrimp growth and immune health.

An Alltech solution that has been effective in field trials in Southeast Asia is Aquate™ Defender.

What is Aquate Defender? It is a blend of organic trace minerals (zinc and selenium) and Saccharomyces cerevisiae yeast extract. This product has been shown to help improve performance and bolster the immune system, ultimately increasing the profitability of the farm.

Aquate Defender is the solution platform for aquaculture that provides a combination of technologies based on proprietary processes. Aquate Defender technologies help maintain a protective balance between your aquaculture species, their nutrition and the environment in which they live. This optimizes animal performance and helps maintain healthy populations.

Researchers at Alltech have developed the Aquate Defender range of nutritional solutions in partnership with our global customer base, using our three core technologies: peptide technologies, solid-state fermentation (SSF) and yeast fermentation. Aquate Defender is specifically designed to address producers’ concerns about the gastrointestinal stability of their animals. Aquate Defender solutions help producers as they work to achieve their animals' true potential and enhance their profitability.

About Aquate Defender:

• Promotes good bacteria and builds defenses
• Promotes gastrointestinal integrity and stability
• Enhances nutrient utilization
• Reinforces the function of the digestive system
• Optimizes performance and profitability

Aquate Defender can improve the gut microvilli length, thus improving overall nutrient absorption, which can translate to growth performance (see Figure 1 below).

Figure 1: Shrimp gut morphology after feeding Aquate Component for 56 days

Intestinal morphology of shrimp fed with Aquate over 56 days

Source: Zhang et al., 2012

The results of a commercial trial at a Malaysia shrimp farm studying the whole production cycle showed that Aquate Defender helped improve overall profitability. The average bodyweight of the harvested shrimp increased 0.77 g, and FCR was reduced by 0.24. Overall, the yield per hectare increased 1.96 tons per hectare, and the return on investment (ROI) for the application of Aquate Defender was 7 to 1, compared to the control.

Figure 2: Results of a commercial trial of white shrimp showing improved performance with Aquate Defender

By improving food absoption and gut health, Aquate Defender increased bodyweight and production.

Source: A large farm in Malaysia (Sept. 2012)

Research and local field trials conducted in Malaysia and Indonesia have proven that, when Aquate Defender is used, the shrimp gut is heathier, with a longer and better villi structure that leads to better absorption. Farmers using Aquate Defender in their nutrition programs are experiencing more successful rates of shrimp culture. In several Asian countries, customers who have previously used Aquate Defender continue to use this product in their feeding programs. 

Although shrimp disease is the main challenge in shrimp culture, it can be prevented and overcome with good farm management practices and a strong biosecurity system. As an animal health and feed additives company, Alltech and its solutions can support you by improving the immune health of your shrimp and increasing both your productivity per hectare and, ultimately, your profitability.

References

A.P. Shinn, J. Pratoomyot, D. Griffiths, T.Q. Trong, N.T. Vu, P. Jiravanichpaisal and M. Briggs (2018). Asian Shrimp Production and the Economic Costs of Disease. Asian Fisheries Science, 31S (2018): 29-58.

FAO (2012). Species Fact Sheets: Penaeus monodon (Fabricius, 1798). In: FAO Fisheries and Aquaculture Department. http://www.fao.org/fishery/species/3405/en

FAO (2013). Report of the FAO/MARD Technical Workshop on Early Mortality Syndrome (EMS) or Acute Hepatopancreatic Necrosis Syndrome (AHPNS) of Cultured Shrimp (under TCP/VIE/3304), 2013. Hanoi, Vietnam, 25–27 June 2013. FAO Fisheries and Aquaculture Report No. 1053, Rome, Italy, 54 p.

HONG X.P., XU D., ZHUO Y., LIU H.Q. & LU L.Q. (2016). Identification and pathogenicity of Vibrio parahaemolyticus isolates and immune responses of Penaeus (Litopaneus) vannamei (Boone). J. Fish Dis., 39, 1085–1097.

NACA (2012). Report of the Asia-Pacific emergency regional consultation on the emerging shrimp disease: Early mortality syndrome (EMS)/acute hepatopancreatic necrosis syndrome (AHPNS), 9–10 August 2012. Published by the Network of Aquaculture Centres in Asia-Pacific, Bangkok, Thailand.

Newman, S. (2015). Microsporidian impacts shrimp production. Global Aquaculture Advocate. https://www.aquaculturealliance.org/advocate/microsporidian-impacts-shrimp-production/

OIE (2019). Manual of Diagnostic Tests for Aquatic Animals – 14/11/2019. https://www.oie.int/fileadmin/Home/eng/Health_standards/aahm/current/chapitre_ahpnd.pdf

Sánchez-Paz, A (2010). White spot syndrome virus: an overview on an emergent concern. Vet Res. 2010 Nov-Dec; 41(6): 43. Published online 2010 Feb 26. doi: 10.1051/vetres/2010015

Sritunyalucksanaa, K., l Intaraprasonga, A., Sa-nguanruta, P., Filerc, K., Fegand, D. (2011). Organic selenium supplementation promotes shrimp growth and disease resistance to Taura syndrome virus. Science Asia 37 (2011): 24-30. doi: 10.2306/scienceasia1513-1874.2011.37.024

Zhang, J., Liu, Y., Tian, L., Yang, H., Liang, G., Xu, D. (2012), Effects of dietary mannan oligosaccharide on growth performance, gut morphology and stress tolerance of juvenile Pacific white shrimp, Litopenaeus vannamei. Fish & Shellfish Immunology 33 (2012) 1027-1032. https://www.hinter.com.cn/Upload/pdf/en/4.pdf

I want to learn more about aquaculture nutrition.

African swine fever (ASF) is a highly contagious and deadly disease that affects domestic and wild pigs regardless of age and sex. ASF cannot be spread to humans and other non-swine animals and livestock and is not a threat to human health. However, humans can carry the virus on their clothing, shoes and equipment and can spread the disease unknowingly.

Historically endemic to African countries, ASF has been spreading rapidly throughout Asia and parts of Europe through 2018 and 2019. What are the symptoms of ASF, what can we do to prevent the disease, and are there any treatment options?

Signs and symptoms of ASF

• High fever (40.5–42oC)
• Sudden loss of appetite
• Hemorrhages on skin and internal organs, particularly lymph nodes
• Diarrhea, vomiting (sometimes with bloody discharge)
• Abortion
• Depression
• Coughing
• Difficulty breathing
• Sudden death
• High death loss

While these symptoms are similar to classical swine fever (CSF), ASF is caused by a unique virus that is distinct from CSF. Unusually high mortality rates among pigs of all ages can be a strong indicator of ASF. However, the only way to know for sure which virus pigs might be infected with is through laboratory testing. If you notice any of the symptoms mentioned above in your herd, contact a vet as soon as you can to ensure that the correct quarantine and treatment are completed. This could help limit the damage on your farm.

Tips to prevent ASF from entering your farm

It is possible to keep ASF out of the farm, even in countries where ASF is endemic. Here are nine prevention measures you can take to avoid ASF.

​

1. Implementation of strict importation measures for animal products:

Ensure that neither infected live pigs nor pork products are introduced into areas free of ASF. ASF-positive countries can have their animal exportations restricted or prohibited as a result of the detection of infected meat. Check infected regions before importing products that could potentially be contaminated.

2. Proper disposal of all food waste from aircrafts or ships coming from infected countries.

Furthermore, no human food waste should be fed to pigs.

3. Efficient sterilization and disposal of garbage: Avoid swill feeding (i.e., garbage feeding).

Feeding of catering waste is a high-risk practice; if the food waste is contaminated with ASF, it can infect a healthy herd. Do not expose food waste that wild swine species could access. Carcasses, discarded parts from slaughtered pigs and food waste should be disposed of appropriately. 

4. Rapid slaughtering of all pigs, infected or not (stamping out):

Recovered or surviving animals are virus carriers for life. Therefore, to avoid spreading the disease to other pigs and to prevent relapse, it is safer to slaughter both infected and potentially infected pigs. Stamping out tends to be a short-term method to eradicate the disease. Nevertheless, it is generally the most cost-effective method that allows farms to be free from ASF in the shortest time.

5. Strict on-farm biosecurity:

Keep viruses and bacteria out by complying with biosecurity rules, including proper disinfection of clothing and boots, as well as not bringing pork products that have not been properly heat-treated onto a farm. Farms should maintain dedicated footwear and clothing that stay on the farm.

6. Controlled animal and human movements:

Pigs should be sourced from trusted and certified suppliers. Vehicles, equipment and people are also fomites of ASF. Ensure that anyone who enters the farm has not been in contact with any other pigs over the past 48 hours. Farm visitors who have been in countries that are ASF-positive need at least five days of downtime before entering the farm. Vehicles and equipment should be properly cleaned and disinfected before entering the premises. As secretions and excretions from sick or dead animals are a source of ASF, carcass-hauling trucks are high-risk and should not enter the farm.

7. Disease surveillance and monitoring:

This is especially important when transporting live pigs and pork products. In addition, pig farms should maintain a strict health monitoring program. All sick or dead pigs should be inspected and examined for ASF. To detect ASF early, pigs slaughtered for own-home consumption should be inspected by an official veterinarian. Regarding staff training, holding regular prevention lectures and strengthening quality assessments as well as the daily records of feed ingredients is advised.

8. Efficient and early detection of the virus through laboratory tests:

Notify a vet immediately upon spotting signs of ASF, and get the pigs tested.

9. Strict quarantine protocol:

Strict quarantine measures should be applied in both ASF-free zones and infected zones to prevent the entry of the disease and/or to keep ASF from spreading further.

Treatments for ASF

• Currently, there are no treatments or vaccinations available for this animal disease.
• Preventative and cautionary measures can be taken to protect animal health.
• Contact between sick and healthy animals can transmit ASF. Therefore, infected animals must be isolated and culled immediately upon confirmation of ASF.

Did you know?

• North America and the Oceania region remain the only areas that have never had reported cases of ASF.
• ASF poses no risk to human health. Humans cannot get infected by ASF.
• ASF infects domestic and wild pigs, as well as a variety of soft-bodied ticks.
• Wild boars and warthogs can be carriers of ASF. Make sure they don’t come in contact with domestic pigs.
• Frozen meat from infected pigs can harbor the virus for up to six months.
• The ASF virus has been estimated to survive for up to 15 days in feces and five days in urine at 21°C.
• It takes 30 minutes of cooking at 70oC to deactivate ASF in meat products and 30 minutes at 60°C for serum and body fluids.
• Curing or smoking pork products does not destroy the virus.
• ASF can be transferred via feed (Niederwerder, et al., 2019). It is important to work with trusted suppliers and vendors to verify ingredient sources and determine what their biosecurity and quality programs entail.

The importance of feed safety and a favorable health status

Studies have shown that feed can be a carrier of certain harmful pathogens (Dee, et al., 2018). As an added layer of protection, put safeguards in place and utilize feed intervention technologies, such as acidifiers, to support the integrity and quality of your feed.

Acidifiers are known to have beneficial properties that “control bacterial growth in feed, […] inhibiting growth of pathogenic microbes” (Jacela, et al., 2009).

Products such as Guardicate™* have been shown to be effective for promoting feed safety and can be used as an important component of your farm’s greater biosecurity program. Over almost four years of research, Guardicate has shown its effectiveness as an acidifier, as it addresses feed quality concerns by helping maintain a favorable feed environment.

Together with other solutions, like Sel-Plex®, Bioplex® and Actigen®, Alltech’s nutritional technologies provide peace of mind that you are safe from the risks that could negatively impact your production while promoting a positive health status for your animals.

Improper mineral supply can have major consequences for the health and productivity of your herd. Improved mineral status has been shown to have a positive effect on immune function. The Alltech Mineral Management program focuses on feeding organic minerals such as Sel-Plex and Bioplex, which are better absorbed and utilized by the animal and, thus, can meet their nutrient needs for optimal health.

Gut health and the microbiome also play a key role in maintaining the overall health status of the pig. Actigen is able to support immune function, gut microbial health and gut function and development, promoting overall animal health and performance.

*Guardicate is only available in select countries.

References:

Dee, S. A., Bauermann, F. V., Niederwerder, M. C., Singrey, A., Clement, T., de Lima, M., & Petrovan, V. (2018). Survival of viral pathogens in animal feed ingredients under transboundary shipping models. PloS one, 13(3), e0194509. https://doi.org/10.1371/journal.pone.0194509

Jacela, J.Y., DeRouchey, J.M., Tokach, M.D., et al. Feed additives for swine: Fact sheets – acidifiers and antibiotics. J Swine Health Prod. 2009;17(5):270–275. https://www.aasv.org/shap/issues/v17n5/v17n5p270.pdf

Niederwerder, M. C., Stoian, A., Rowland, R., Dritz, S. S., Petrovan, V., Constance, L. A....Hefley, T. J. (2019). Infectious Dose of African Swine Fever Virus When Consumed Naturally in Liquid or Feed. Emerging Infectious Diseases, 25(5), 891-897. https://dx.doi.org/10.3201/eid2505.181495

I would like a FREE Feed Safety Guide.

Transportation stress is an unavoidable factor for any beef operation. Treating transportation stress in cattle is a challenge, however, the negative health effects incurred by transporting animals can be limited by implementing a number of good management practices. These key steps are simple and can be easily adopted by your operation today.

Step 1: Identify your specific risk-factors

Some common factors that will increase the effects of transportation stress in calves include animal cramming, excessive trailer movement, heat stress, dehydration, introduction to new pathogens and inadequate receiving protocols. Even though this list may seem long and broad in focus, there are simple steps you can take to drastically decrease each of these risk-factors.

Step 2: Incorporate Beef Quality Assurance certifications

Once animals are loaded onto a trailer, it is paramount that the truck driver is intentional about how the animals are treated in order to reduce stress. Ensuring that the driver has a Beef Quality Assurance: Transportation Program certification can provide peace of mind that the animals will be handled adequately. Through these programs, drivers learn to avoid common pitfalls like fast starts/stops/turns, become aware of cold and hot temperature concerns, and focus on cattle handling during loading and unloading. Avoiding these stressful behaviors improves your chances of receiving healthy cattle.

Step 3: Develop a receiving protocol

The risk of transportation stress does not end when the animal is received. While you have less control over managing stress during transport, the risks still remain in the hands of feedlot personnel. The solution starts with implementing a proper receiving protocol that is based on low-stress handling. The calmer and quieter the employees are, the calmer and quieter the animals will be. This can be accomplished by avoiding hot-shot use, not yelling around animals and removing loud equipment (e.g., hydraulic pumps) from the chute area. A Beef Quality Assurance: Stockmanship Program is also available for employees and is highly valuable for training proposes.

Step 4: Pay attention to what you cannot see: Internal health

While you can limit external stressors such as noises, excessive movement and stressful animal experiences, an often-forgotten risk factor is the internal heath of the animal. The stress of transportation and the introduction to a new environment, new feedstuff and new pathogens will often result in some level of digestive distress. A decrease in feed intake, feed conversion and weight gain may be observed, and the culprit is almost always due to an immune response in the animal’s digestive tract. The digestive system is very complex and can be damaged easily when health is neglected. The cause of this damage can range from temperature changes to new feedstuffs — even to new bacterial populations. Most of these stressors are unavoidable due to the nature of the uncontrollable environment, and thus, preventative measures must be taken.

Step 5: Rely on supplements during the transition period

At Alltech, we are passionate about improving animal health through digestive and immune protection, correction and optimization. In our beef division, we focus heavily on reducing animal stress to improve overall growth and health, which simultaneously improves your bottom line. This is demonstrated in Select TC, our feedlot product, which aims to relieve digestive stress during the arrival of a newly introduced animal. The gut has a major impact on the rest of the animal, but because we are unable to see it, we often overlook this factor when considering an animal’s potential. When a gut becomes agitated and inflamed from poor feed quality, new bacteria or stress, you will see animal performance suffer greatly. This decrease in performance is due to the level of energy the immune system requires to fight off pathogens, heal the damaged tissues and produce an overall immune response. Utilizing a supplement to help the immune system protect the animal and negate the effects of the pathogens can help the animal transition into a feedlot more effectively. A more effective transition will, in turn, allow cattle to consume more feed and gain more weight without wasting energy on immune functions, increasing your profitability.

Select TC is a well-rounded receiving-period supplement with benefits ranging from gut-cell health support to decreasing the repercussions of bacteria and mold in the animal’s body. This product can be fed in many different forms and at various dosage levels depending on your specific operation.

Protect your herd from these common pitfalls, which can lead to low-performing animals. Contact your local Alltech salesperson or beef@alltech.com to learn more about what Select TC can do to help limit your fallout from transportation stress and get your cattle on feed faster.

I would like a FREE transportation stress poster.

According to the Centers for Disease Control and Prevention (CDC), Salmonella is the cause of an estimated 1 million food-borne illnesses in the United States every year, including 19,000 hospitalizations and more than 300 deaths. The most common symptoms of a Salmonella infection are diarrhea, fever and abdominal cramps. Serious Salmonella infections are more likely to manifest in those who are under 5 years old or are over 65 years old, or in those with weakened immune systems (e.g., diabetics or cancer patients). Although illness from Salmonella is often the result of improper food preparation or several other factors, poultry producers and backyard flock owners can help reduce consumer risk through good management practices.

Potential sources of bacterial contamination include: 

• Wild birds/pests (e.g., beetles, flies or rodents) 
• Water 
• Visitors 
• Hygiene 

In poultry production, there are eight key areas that must be given attention in order to reduce bad bacterial contamination on-farm and aid in the prevention of Salmonella.

1. Clean facilities and dedication to biosecurity:  Residual contamination from previous flocks is a common cause of Salmonella in birds. Cleaning areas that birds often touch (e.g., drinking and feed containers) or frequent (e.g., the coop) before the birds arrive and after they leave can help reduce the prevalence of Salmonella. Effective biosecurity and pest control are also key to avoiding contamination in the coop. 

2. Feed:  Contaminated grains and feed ingredients can increase the risk of Salmonella in the final feed. Use heat-pelleted feed, and source feed from mills that maintain stringent quality standards. 

3. Water management:  Water management is a crucial part of any Salmonella control program for poultry, since water can serve as a medium for the organism to spread from bird to bird. Chlorination, as well as the use of organic acids in drinking water, can help to reduce Salmonella levels in the flock. 

4. Dust:  Like water, dust can also foster the spread of Salmonella. Try to keep dust levels in and around the coop below 3 milligrams per cubic meter. 

5. Litter and manure management:  Poultry litter and manure with high moisture and pH levels allow Salmonella to thrive. Managing the moisture and pH of the litter and manure can be effective ways to prevent it from spreading. 

6. Managing gut flora: Establishing and maintaining proper gut flora soon after hatching is critical for mitigating Salmonella contamination. Programs that include the use of probiotics, organic acids, enzymes and yeast technologies have proven effective at maintaining optimal gut health. Several Alltech products that can support gut health — including Sel-Plex^®, Bioplex^®, Allzyme^® ;SSF, Bio-Mos^®, Yea-Sacc^® and Integral^® A+ — are incorporated into all Hubbard Premium Quality poultry feeds.

7. Coccidiosis: Intestinal challenges caused by poor gastrointestinal integrity can have a major impact on Salmonella levels in broilers. As such, strong coccidiosis management should be part of every Salmonella control program. 

8. Vaccination: Especially at the breeder level, the use of vaccines has the potential to reduce the prevalence of Salmonella among day-old chicks. You should only purchase chicks from a reputable source. While vaccines can be applied to backyard poultry, a poultry veterinarian should be consulted to design a suitable program for your birds. 

Cleaning and personal hygiene for your safety 

People can get sick from eating Salmonella-infected meat or eggs or by touching infected poultry or housing. Birds can carry Salmonella but show no symptoms or signs of illness. Fortunately, however, there are several factors that can boost protection: 

• Always wash your hands with soap and water (or use hand sanitizer) immediately after touching birds, their housing, eggs or meat. Require visitors to do the same. 
• Do not allow backyard poultry inside your home, especially where food or drink is prepared, served or stored. 
• Wear a specific pair of shoes when taking care of or visiting birds that you do not wear elsewhere. Leave this footwear outside and request that visitors to do the same. Rubber boots are a popular option. 
• Do not eat or drink where poultry live or roam. 
• Do not kiss or snuggle backyard poultry and then touch your face or mouth. 
• When cleaning the equipment or materials you use to raise or care for your birds, do so outdoors, not inside.
• Any individuals with potentially weakened immune systems should not touch the birds.
• Source young birds from government-inspected hatcheries or reputable sources that have a bird health plan.
• Maintain a clean coop and collect eggs often. 
• Clean dirty eggs with fine sandpaper, a brush or cloth — but DO NOT wash eggs with cold water, as this can pull Salmonella into the egg.
• Refrigerate eggs after collecting them and cook them thoroughly before serving.

To expand on the CDC statements regarding Salmonella in backyard flocks, many of these precautions should also be applied when going to a feed or retail store that offers baby chickens, turkeys and/or ducks for purchase. Many stores are now enclosing the birds in an effort to discourage handling, but it is still a good idea to wash and/or sanitize your hands prior to leaving the store.

Additionally, take extra precautions when cooking or handling raw chicken. Try to limit the exposure of raw chicken to temperatures above 40 degrees Fahrenheit (e.g., leaving raw chicken out on the kitchen counter). Always cook poultry thoroughly — use a meat thermometer to ensure that the proper temperature is met — and disinfect surfaces where meat was stored or prepared. The safe internal temperature for cooked chicken is 165° Fahrenheit (75° Celsius).
 

For more information, please refer to the following articles from the CDC:  

https://www.cdc.gov/features/salmonellapoultry/index.html 

https://www.cdc.gov/salmonella/backyardpoultry-05-19/index.html  

I want to learn more about poultry nutrition for my flock.

Can gut health improve efficiency on poultry farms? John Cooper, Alltech poultry technical manager for the U.K., explains the science behind gut health and the benefits that come with being proactive in addressing on-farm concerns.

The following is an edited transcript of Kara Keeton’s interview with John Cooper. Click below to hear the full audio.

Kara:              I'm here today with John Cooper, the Alltech poultry technical manager for the United Kingdom. Thank you for joining me today.

John:              Thank you for having me.

Kara:              John, have you always been interested in poultry production?

John:              Yeah. I actually started off when I was 15, just working on breeder farms through spread and feed, and went my way up to managing the different types of the integration — so broilers, layers, rearing birds and even hatchers, as well — so I’ve kind of grown up with the industry, I suppose.

Kara:              You've been with Alltech five years now, correct?

John:              Correct, yeah.

Kara:              What has your experience been like in working with Alltech and the research and challenges you’ve faced in the industry?

John:              The research side, I've actually found really interesting, because we've done quite a lot of that in the U.K. as well, so the information that we get is relevant. From the point of view of how I’ve found it, the whole industry really shifted, I suppose, with the onset of reducing antibiotic use and things like that, so it kind of came towards what Alltech was about, whereas I think, beforehand, it was not really something people had to do. Now, with the industry changing, we're very much in the right space, and we have the information, the data and the products to support what we're trying to do.

Kara:              And what you're trying to do with your research and, especially, with Alltech products is to look at ways to reduce antibiotic use within the industry, so tell me a little bit about how you have been working on research projects in that avenue.

John:              Okay, so, really, what we've been doing is looking at how our products interact with the microbiome — for instance, how it improves the structure of the villi, all these things that really contribute to the processes of poultry production, how we're basically going to get the biggest bang for our customers' buck, really. Also, when you're thinking of gut health, it's, first, limiting, so it's really about how you can improve gut health to achieve the performance that the birds are actually supposed to do.

Kara:              Gut health is always an interesting topic to me. What exactly is gut health, and how can you improve it with some of the research developments?

John:              Gut health is looking at how the microbiota, the feed — how the bird can basically use what you're providing it as tools so as not to have to use medication. By improving gut health, the birds, then, can withstand the challenges that they get from everyday processes. So, really, gut health is like the engine; you put good oil in it, you service it often and it all works properly. That's where we come in, by showing and using research to, really, I suppose, put a focus on — you can actually see the developments and what changes.

                        We've done a lot of work on the microbiota, seeing how the microflora play a big part in what happens with the chicken or any other animal that we work with. We can see the shift in the diversity and how that's important to achieving gut health. I try and explain it to my customers as simply as possible, because it's quite a tough subject to talk about. I would say it's like, in the U.K., we have the House of Commons. So, you have all these seats that are empty, and then you put the right people in those seats, you fill those seats, and then things that want to invade — like campylobacter, E. coli, all these things — those things then can't invade because you've already got a set presence there, so it kind of really does reduce the challenge when they get these coming on.

Kara:              I've heard the terms “postbiotics” and “probiotics”. Can you explain this to me and tell me how they impact gut health?

John:              Postbiotics are a byproduct of the fermentation of when we use prebiotics and they feed the probiotics. Probiotics are something that you're trying to give the animal a dose of, that either could be from the mom, I suppose, in a way, or even a beneficial bacteria. Like I mentioned about filling the seats in the House of Commons, you're trying to fill those seats as fast as possible, and then, the prebiotics are really there to improve the level of the bacteria that are not the good guys, that you're not wanting, so that'll remove them but also to promote the good guys, by doing that. I suppose, in a way, postbiotics is looking at what the byproducts are — so things like organic acids, enzymes, all these things that are beneficial to the bird. It helps with reducing E. coli coming from the alkaline living area, where it wants to be, and not actually getting into the more acidic area, which you're trying to keep them out of, so we find that organic acids work really well.

Kara:              Now, I read about the “seed, feed, weed” strategy. Explain that to me. I think it's a very interesting approach.

John:              Okay. Really, it's a concept that was developed by Dr. Steve Collett at the University of Georgia.

                        What you do is you're seeding the gut dam with the right commensal bacteria; then you're feeding that with organic acids, basically, so you can actually promote the good guys and also stop the bad guys from invading, as I mentioned, by keeping the area at a lower-acid pH level. Then, also, the weed part is weeding out the bad guys, the unwanted, and promoting the good guys. That's the concept, pretty much. It's a nice, simplified way of doing things, but what I find from working with customers is, whether we put one part together and then we add the other part so you could do the whole program, it's not something that happens overnight. It really is a whole different way of managing a farm. It's a different way of thinking in terms of — there are so many little bits. You've got to be more proactive than reactive.

                        Also, the biggest benefits come three to five flocks afterwards, because you're not just changing the microbiota of the chicken. You're not just working on that area; you're also seeing this happen on the farm. So, you go from an antibiotic background, where your bacteria could be high levels, even though, in the U.K., we clean out and disinfect. The profile doesn’t change; we lower the dose, but the profile doesn’t change, so it's how, then, we can make sure that what the bird first comes into contact with when it gets placed on the farm is actually more beneficial than what it's going to get from a more beneficial bacteria — so, something that we get that's more useful to them. So, you're shifting from an antibiotic to a more probiotic background, and that's where you start seeing that three-to-five flocks being really important to understand, where, once you hit that, there is a bigger benefit that comes after. Of course, good breeds good, so the more little pooping machines you have running down, spreading the better bacteria and promoting that, then everything works really well.

Kara:              So, when you are taking a more proactive approach to addressing concerns on the farm, this also has to have an impact on the bottom line for the farmers. What are the farmers seeing when they transition to this more proactive approach, instead of leaning and depending on antibiotics?

John:              As I mentioned, it's the evolution of the whole farm. Well, not just the farm, but the sheds as well. Really, being proactive, I suppose it's bringing the management style back to the manager that manages the farm, looks at the signs. There's a lot of technology out there, but you still can't get away from — you can't beat what the bird tells you. They tell you when it's too hot, too cold, or something is not right, so it's really stockmanship. You can't really put a price on that, and I think that's where “seed, feed, weed” really does bring it back to the stockman, to work with the animals and, I suppose, use the tools that are available and use them as best as possible to get the best results.

Kara:              How do you see the development of a proactive approach, a sustainable approach, impacting poultry production down the road five to ten years? Do you see this as being a progressive approach that more and more farmers are adapting?

John:              I think everybody is doing something similar to a “seed, feed, weed” approach. Sometimes, they're not doing it how we would do it, but that's the whole point of it; it's a concept that gives you an idea of how to do something better and different. So, really, I think, as we understand what happens and what changes, I think it really does open your eyes, and then, you're able to actually see right, like, “I understand this is what's happening,” and it kind of makes sense in your head. It's just a different way of reacting to things, rather than picking up the phone and calling the vet. That's a cost as well, so it's kind of how you take things into your own hands and manage what's happening on your farm. I think, going forward, I think it's only going to become more and more important with the more information and research different companies are putting out there, whether it be Alltech or someone else. I think it's all very relevant, and the more we know, then the more we can actually say, “Well, this is what's actually interacting with our animals in a certain way,” and we’ll know how we can correct that.

Kara:              Okay. Thank you so much for joining me today, John. This is John Cooper, Alltech poultry technical manager for the United Kingdom.

I would like to learn more about gut health for my poultry farm.