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Organic trace minerals for pets’ brain health

August 12, 2021
Dog and cat in field

Alongside the widespread growing awareness of our own health and wellness, there also seems to be a deepening interest in improving the overall health and longevity of our pets. With pets living longer and a large percentage of pets classified as obese, it comes as no surprise that we are seeing a rise in associated health issues, including osteoarthritis, diabetes, heart disease, hypertension, certain types of cancers and cognitive decline.  

How can we address some of these challenges, especially those related to cognitive function in pets?

1. Take a preventative, nutrition-based approach.

"Pet Gut health and immunity"

Providing proper nutrition is still considered one of the most effective and financially viable ways to decrease an animal’s disease risk. An important part of any animal’s health and diet is immuno-nutrition, which can be defined as the effect of providing specific nutrients — typically, a combination of certain amino acids, nucleic acids, vitamins and minerals — on the animal’s immune system.

With the direct link between a healthy digestive system and immunity, the importance of gut health cannot be overstated. Gut health, immunity and the microbiome have also been shown to be linked to cognitive health. Research in this area has proven that the gut and the brain communicate regularly through a highly complex interactive system. This highlights the important role of nutrition, not only for the growing and developing puppy, but for the aging or senior dog as well.

2. Optimize gut health by increasing microbial diversity.

"Pet microbiome"

Gut health can be improved and maintained in several ways, but increasing microbial diversity — as well as reducing pathogens and increasing beneficial bacteria, such as the Lactobacillus and Bifidobacteria species — is key. Adding prebiotics, probiotics and postbiotics to an animal’s gut health program has been well-researched and established as important for maintaining good gut health. Furthermore, products such as mannan-rich fractions of yeast (MRF) and certain fermentation solubles — including mannan oligosaccharides (MOS) — as well as nucleotides and branched-chain amino acids are being incorporated into pet food for dogs and cats at a growing rate.

  • Senior or geriatric dogs tend to have reduced concentrations of Bifidobacteria species, and studies of MOS have shown that they are correlated with significant increases in beneficial populations, which can help offset the negative effects of age on colonic health.
  • MRF have also proven to be beneficial in pet diets in several ways. They basically provide a source of attachment for certain pathogens and escort them through the digestive tract, preventing colonization and reversing dysbiosis. MRF also support nutrient utilization, help maintain digestive function and enzyme activity and work to control inflammation.

3. Support immunity and cognitive health in dogs and cats with antioxidants.

"pet omega-3 fatty acids"

We’ve looked at how immuno-nutrients affect gut health, but what impact do they have on the overall immune system? Trace minerals are essential in many metabolic and physiological processes, and using the organic, more bioavailable form of these essential nutrients has been proven to be beneficial in multiple ways.

Recent companion animal studies of Bioplex® and Sel-Plex® showed that, even when supplemented at much lower levels than their inorganic counterparts, these two products supported and promoted better trace mineral status, bone mineral density, growth and immune measures in both cats and dogs.

Certain trace minerals, including selenium, are also known to be important antioxidants. Since antioxidants can help minimize free-radical formation and oxidative stress, including them in pets’ diets is often considered an important part of any immune-nutrient strategy to help prevent and managed age-related health issues.

Some of the leading age-related health problems in pets include immune-related issues, joint health, cancer, diabetes and heart disease. Two other emerging concerns and interests for pet owners with older pets are cognitive health and function.

When it comes to cognitive health, there have been several studies linking antioxidants and their role in counteracting oxidative stress to potential improvements in cognitive performance.

It seems that impaired neuroprotection that results from oxidative stress has been implicated in neurodegeneration, and as such, inhibitors of oxidative damage — especially antioxidants — are considered very promising as potential preventatives. 

Selenium is considered to be not only a very powerful antioxidant but a major agent of immune stimulation as well. Several studies in humans, companion animals and other species have shown that selenium can reduce oxidative damage, optimize immunity and thyroid health, and even help prevent mental decline.

The problem with selenium is that its availability, utilization and efficacy depend on the dietary source or form in which it is provided. Inorganic selenium (i.e., sodium selenate or sodium selenite), the most widely used form of selenium, is not only highly toxic; it is also poorly absorbed, can induce DNA damage and can have very strong pro-oxidative properties, making it a poor choice as an antioxidant. Because of toxicity concerns, inclusion rates for selenium are regulated, and the suggested levels are set with an eye toward preventing a deficiency rather than supplementing for optimized immunity and health. As such, it is worthwhile to reconsider our selenium supplementation strategies and find ways to maximize selenium status that, ultimately, support cognitive health as well.

An animal’s selenium status can easily be improved by substituting inorganic selenium with the organic form of the mineral, such as that included in Sel-Plex. Studies of Sel-Plex have evaluated its potential antioxidant characteristics in several species, including transgenic mice, and the results have shown a substantial increase in glutathione peroxidase and significantly decreased levels of DNA and RNA oxidation. Poor selenium status, on the other hand, has been linked to an increased risk of heart disease.

Selenium has been shown to lower markers of inflammation, indicating that it may help decrease an animal’s risk of heart disease by reducing inflammation and oxidative stress, which have been linked to atherosclerosis. Since pets are also susceptible to certain heart conditions, implementing nutritional strategies to improve selenium status and, in turn, reduce oxidative stress and any subsequent inflammation could potentially have positive benefits for geriatric pets as well.


Thanks to the growing trend of increased awareness and interest from pet owners about the overall health and well-being of their animal companions, we can expect nutrition to play an even more prominent role as part of a preventive approach to maintaining pet health. The importance of the pet microbiome cannot be underestimated, as it serves as the foundation of a healthy GI tract, immunity and overall health through all life stages. When looking at antioxidants, the opportunity also exists to make seemingly small changes — like switching from inorganic selenium to an organic source — that can actually have a significant impact on the overall immunity, health and cognitive function of the animal. Immuno-nutrients will continue to be an important part of a targeted nutritional approach to caring for pets, but it is also important to look for product-specific research and validation when creating your pets’ health plan.


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