Selenium supplements are available in several forms; inorganic mineral salts, such as sodium selenite or selenate; organic forms, such as selenium-enriched yeast in which selenoamino acid analogues such as selenomethionine predominate; or chemically synthesised selenoamino acids and selenoamino acid analogues produced by synthetic routes. The distribution and accumulation of selenium and selenium form in animal tissues depends greatly on the type of selenium supplement, and the form in which selenium is presented will play a crucial role in its bioavailability and efficacy. Organic forms of selenium are the optimal nutritional source, and upon uptake within the cell, they get transformed into common seleno-intermediates for further utilisation and/or excretion.

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