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Vivi Koletsi

Vivi Koletsi  profile image

Vivi Koletsi

PhD Candidate

Vivi Koletsi is a biologist specialized in aquaculture and specifically in fish nutrition, health and welfare. She had graduated from Wageningen University (MSc. Aquaculture and Marine Resource Management) and worked for her MSc. internship at Alltech Coppens establishing a protocol to prevent mycotoxin contamination in aquafeeds. Earlier, she had obtained her BSc degree in Biology from Aristotle University of Thessaloniki, Greece. Currently, she is a PhD researcher at Alltech Coppens/Alltech and Aquaculture and Fisheries Group (AFI), Wageningen University, the Netherlands.

Her project aims to deal with the negative effects of mycotoxins in the aquaculture industry, using rainbow trout (Oncorhynchus mykiss) as a model species. Besides the standard measurements on growth performance and body composition, specific emphasis will be given on the effects of mycotoxins on the gut barrier, liver health and immune response. Gut barrier function will be tested by histology and gene expression of tight junction proteins (Claudin-15; Claudin-25b; Occludin; Tricellulin; ZO-1). Liver health will be assessed by histology and measuring oxidative stress and health biomarkers (TBARS, ALAT, ASAT, LDH). Potential immunomodulating properties of mycotoxins will be investigated by gene expression of cytokines (IL-1β, IL-6, IL-8, IL-10, TNF-α, IFN-γ). Real-time RT-PCR is the main molecular technique will be used to measure the expression of selected genes. Finally, in vitro models with intestinal and liver cell lines will be used to get a complete picture of the effects of mycotoxins on the health of rainbow trout.